HitPredict

Interactor 1: B5B2U4 (B5B2U4)
Nuclear factor of activated T-cells c3 isoform IB-Xa
Gene: Nfatc3

Interactor 2: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16260608
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1068 Mm			1 235
+	Hs
		378075 NFAC3_HUMAN (1-1035): 6.1e-156: 492: 89.96		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Hs
		164686 NFAC3_HUMAN (1-1035): 6.1e-156: 492: 89.96		TNF11_HUMAN (49-235): 5.31e-58: 188: 20.10
+	Mm
		449235 NFKB1_MOUSE (421-939): 3.62e-107: 359: 15.68		TNFA_MOUSE (1-235): 4.52e-105: 305: 100.00
+	Hs
		378084 NFAC2_HUMAN (39-1003): 8.04e-80: 282: 32.62		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Hs
		340802 NFAC1_HUMAN (19-880): 7.98e-77: 274: 38.67		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Hs
		378095 NFAC4_HUMAN (1-864): 1.17e-70: 255: 39.80		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Mm
		449241 RELB_MOUSE (382-848): 1.09e-61: 222: 15.86		TNFA_MOUSE (1-235): 4.52e-105: 305: 100.00
+	Hs
		378061 RELB_HUMAN (327-848): 5.7e-57: 209: 15.67		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Mm
		449240 TF65_MOUSE (418-904): 2.8e-48: 183: 19.11		TNFA_MOUSE (1-235): 4.52e-105: 305: 100.00
+	Hs
		378066 TF65_HUMAN (416-904): 1.32e-47: 181: 18.37		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Hs
		321949 NFAT5_HUMAN (319-936): 3.09e-45: 180: 27.14		TNFA_HUMAN (1-235): 2.11e-104: 303: 78.39
+	Mm
		449256 NFAT5_MOUSE (319-936): 2.35e-42: 171: 26.17		TNFA_MOUSE (1-235): 4.52e-105: 305: 100.00
+	Hs
		715433 REL_HUMAN (429-1038): 6.15e-105: 343: 18.59		CD40L_HUMAN (83-235): 6.85e-37: 131: 22.98
+	Hs
		715437 NFAC2_HUMAN (39-1003): 8.04e-80: 282: 32.62		CD40L_HUMAN (83-235): 6.85e-37: 131: 22.98
+	Hs
		340832 NFAC1_HUMAN (19-880): 7.98e-77: 274: 38.67		CD40L_HUMAN (83-235): 6.85e-37: 131: 22.98
+	Hs
		869526 MYO15_HUMAN (34-502): 1.21e-32: 140: 15.15		TNFL6_HUMAN (19-235): 1.22e-64: 203: 26.34