HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	15009096
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000775 - chromosome, centromeric region GO:0000779 - condensed chromosome, centromeric region GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005721 - pericentric heterochromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 140 Hs			1 183
+	Hs
		934721 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800317 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800341 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		934657 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Mm
		935445 H31_MOUSE (5-134): 1.29e-52: 164: 48.86		CBX1_MOUSE (36-180): 1.02e-53: 170: 71.33
+	Hs
		935237 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SUV92_HUMAN (6-156): 4.05e-43: 149: 25.15
+	Hs
		203659 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		203711 H3C_HUMAN (5-134): 5.15e-52: 162: 47.69		SUV91_HUMAN (3-179): 4.73e-40: 141: 16.20
+	Hs
		935387 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CDYL_HUMAN (16-165): 6.53e-34: 127: 25.16
+	Hs
		828384 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		327837 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		828230 CENPA_HUMAN (1-140): 2.13e-55: 171: 100.00		CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00
+	Hs
		123231 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		316000 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		327844 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		123254 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		316040 H31T_HUMAN (5-134): 1.01e-51: 162: 48.09		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		935259 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		934768 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00
+	Hs
		934987 H31_HUMAN (5-134): 1.29e-52: 164: 48.86		CDYL2_HUMAN (28-125): 3.12e-25: 102: 28.43