HitPredict

Interactor 1: IQGA1 (P46940)
Ras GTPase-activating-like protein IQGAP1 (p195)
Gene: IQGAP1

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0019901 - protein kinase binding GO:0030667 - secretory granule membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1657 Hs			1 191
+	Hs
		862792 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		862771 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		862778 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		580922 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		RAC2_HUMAN (1-191): 3.6e-77: 230: 71.35
+	Hs
		466145 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		RHOC_HUMAN (5-191): 1.31e-75: 226: 56.15
+	Hs
		862770 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		RAC3_HUMAN (1-177): 2.18e-74: 223: 72.88
+	Hs
		601208 IQGA1_HUMAN (1-1657): 0: 1729: 100.00		RHOQ_HUMAN (4-189): 5.77e-73: 220: 56.84
+	Mm
		988916 IQGA1_MOUSE (1-1657): 0: 1685: 95.96		RAC1_MOUSE (1-191): 1e-80: 239: 71.88
+	Mm
		953814 IQGA1_MOUSE (1-1657): 0: 1685: 95.96		CDC42_MOUSE (1-191): 2.01e-77: 231: 60.73
+	Hs
		988494 IQGA3_HUMAN (13-1657): 0: 1558: 58.87		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		955338 IQGA3_HUMAN (13-1657): 0: 1558: 58.87		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		962226 IQGA3_HUMAN (13-1657): 0: 1558: 58.87		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		466336 IQGA3_HUMAN (13-1657): 0: 1558: 58.87		RHOC_HUMAN (5-191): 1.31e-75: 226: 56.15
+	Hs
		953538 IQGA3_HUMAN (13-1657): 0: 1558: 58.87		RAC3_HUMAN (1-177): 2.18e-74: 223: 72.88
+	Hs
		601353 IQGA3_HUMAN (13-1657): 0: 1558: 58.87		RHOQ_HUMAN (4-189): 5.77e-73: 220: 56.84
+	Hs
		1015420 IQGA2_HUMAN (254-1657): 0: 1318: 54.09		RHOG_HUMAN (1-191): 1.42e-80: 239: 100.00
+	Hs
		988345 IQGA2_HUMAN (254-1657): 0: 1318: 54.09		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		955140 IQGA2_HUMAN (254-1657): 0: 1318: 54.09		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		953431 IQGA2_HUMAN (254-1657): 0: 1318: 54.09		RAC3_HUMAN (1-177): 2.18e-74: 223: 72.88
+	Hs
		601277 IQGA2_HUMAN (254-1657): 0: 1318: 54.09		RHOQ_HUMAN (4-189): 5.77e-73: 220: 56.84