HitPredict

Interactor 1: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 363 Hs			1 522
+	Hs
		872149 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		129543 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		872150 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Mm
		936293 BAG6_MOUSE (2-307): 4.37e-39: 149: 15.63		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		872183 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12
+	Hs
		1020971 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1020952 UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1313380 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		872214 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		RNF41_HUMAN (55-177): 2.33e-17: 84.9: 33.33
+	Hs
		475011 UBB_HUMAN (3-81): 4.96e-28: 111: 30.38		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1318731 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		TRIM4_HUMAN (61-336): 6.36e-43: 161: 12.90
+	Hs
		803694 BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		1019380 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		803535 BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		1318716 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		584896 BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		536755 BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Mm
		924253 RL40_MOUSE (3-129): 6.2e-38: 134: 22.84		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		1345055 UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57		RN114_HUMAN (63-232): 4.73e-33: 127: 19.13
+	Hs
		924402 RL40_HUMAN (3-129): 1.37e-38: 136: 22.84		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00