HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: SMCE1 (Q969G3)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)
Gene: SMARCE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	28794006, 35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045597 - positive regulation of cell differentiation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 411
+	Mm
		236723 SOX2_MOUSE (1-317): 2.25e-70: 223: 94.67		SMCE1_MOUSE (1-411): 9.28e-78: 248: 97.32
+	Hs
		604618 SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00		UBF1_HUMAN (55-380): 2e-40: 154: 15.29
+	Hs
		872767 SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00		HM20A_HUMAN (3-308): 1.93e-39: 146: 16.08
+	Hs
		1380012 SOX17_HUMAN (7-260): 2.4e-33: 128: 27.80		SMCE1_HUMAN (1-411): 1.29e-78: 250: 100.00
+	Hs
		336282 SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00		SOX14_HUMAN (61-209): 5.77e-35: 131: 17.45
+	Mm
		1049111 Q60I23_MOUSE (1-317): 2.37e-73: 230: 96.24		SOX8_MOUSE (53-224): 2.04e-31: 126: 15.12
+	Hs
		872203 SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00		TFAM_HUMAN (64-259): 3.34e-29: 116: 19.19
+	Hs
		872254 SOX2_HUMAN (1-317): 7.52e-76: 236: 100.00		SSRP1_HUMAN (61-135): 1.2e-21: 99.3: 25.33
+	Hs
		776138 SOX5_HUMAN (2-127): 7.95e-43: 158: 41.27		HM20B_HUMAN (37-302): 6.08e-47: 165: 20.51
+	Hs
		776133 SOX5_HUMAN (2-127): 7.95e-43: 158: 41.27		HM20A_HUMAN (3-308): 1.93e-39: 146: 16.08
+	Hs
		604745 TF7L2_HUMAN (14-255): 1.15e-34: 134: 19.75		UBF1_HUMAN (55-380): 2e-40: 154: 15.29
+	Dm
		121514 M9PFG6_DROME (21-121): 2.57e-40: 147: 78.22		DICH_DROME (5-165): 2e-36: 138: 18.52
+	Hs
		776052 SOX5_HUMAN (2-127): 7.95e-43: 158: 41.27		TFAM_HUMAN (64-259): 3.34e-29: 116: 19.19
+	Dm
		1174466 DICH_DROME (41-117): 1.19e-33: 129: 88.31		DICH_DROME (5-165): 2e-36: 138: 18.52
+	Dm
		120230 M9PFG6_DROME (21-121): 2.57e-40: 147: 78.22		M9PCZ7_DROME (4-176): 1.27e-28: 120: 15.61
+	Ce
		1171149 EGL13_CAEEL (8-178): 6.56e-33: 128: 35.09		EGL13_CAEEL (5-177): 3.37e-31: 126: 19.79
+	Hs
		1024186 SOX17_HUMAN (7-260): 2.4e-33: 128: 27.80		TFAM_HUMAN (64-259): 3.34e-29: 116: 19.19
+	Dm
		1174467 DICH_DROME (41-117): 1.19e-33: 129: 88.31		HMG2_DROME (61-145): 1.16e-13: 73.9: 28.24