HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.710

Property	Details
Experiments	34079125, 10617658, 15811349, 10225955, 23750010
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0044291 - cell-cell contact zone GO:0050839 - cell adhesion molecule binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1824 Hs			1 538
+	Hs
		876510 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NECT3_HUMAN (30-389): 3.83e-72: 241: 25.00
+	Hs
		876471 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NECT4_HUMAN (33-502): 1.4e-66: 225: 21.76
+	Hs
		876389 AFAD_HUMAN (1-1824): 0: 1279: 100.00		NECT1_HUMAN (19-370): 6.64e-58: 203: 34.72
+	Hs
		876467 AFAD_HUMAN (1-1824): 0: 1279: 100.00		KIRR1_HUMAN (33-363): 7.38e-16: 82.9: 16.72
+	Hs
		876457 AFAD_HUMAN (1-1824): 0: 1279: 100.00		TITIN_HUMAN (171-517): 2.2e-09: 62.8: 13.49
+	Dm
		1214097 Q8IPP3_DROME (1-1732): 0: 876: 31.05		Q9VQW7_DROME (23-361): 4.37e-34: 139: 15.95
+	Mm
		1307921 PARD3_MOUSE (937-1811): 1.22e-20: 101: 11.59		NECT3_MOUSE (30-389): 6.35e-71: 238: 25.00
+	Dm
		1364391 Q9VE88_DROME (1001-1160): 2.82e-43: 174: 28.83		Q9VQW7_DROME (23-361): 4.37e-34: 139: 15.95
+	Mm
		1307920 PARD3_MOUSE (937-1811): 1.22e-20: 101: 11.59		NECT1_MOUSE (19-434): 2.81e-61: 211: 30.59
+	Mm
		530208 DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51		NCAM1_MOUSE (33-451): 2.7e-37: 149: 14.06
+	Hs
		1050029 SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85		LRIG1_HUMAN (153-427): 4.08e-34: 139: 14.14
+	Hs
		1077864 GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72		MYLK_HUMAN (158-258): 4.39e-10: 64.7: 11.88
+	Dm
		113767 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		Q9W4T9_DROME (95-465): 1.98e-24: 110: 15.33
+	Mm
		729417 PARD3_MOUSE (937-1811): 1.22e-20: 101: 11.59		VGFR2_MOUSE (55-529): 8.51e-22: 102: 9.85
+	Dm
		113559 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		Q9VQ08_DROME (348-538): 5.69e-20: 96.3: 10.26
+	Dm
		52366 M9NFI9_DROME (1002-1092): 6.19e-22: 106: 38.95		A1Z7J1_DROME (95-334): 1.25e-13: 76: 16.53
+	Hs
		1077872 MYO5A_HUMAN (1369-1800): 2.36e-11: 71.5: 10.74		MYLK_HUMAN (158-258): 4.39e-10: 64.7: 11.88