HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: TRI31 (Q9BZY9)
E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31)
Gene: TRIM31

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	32296183, 19549727, unassigned1304, 32814053
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 425
+	Hs
		896381 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI39_HUMAN (7-378): 6.84e-96: 298: 24.81
+	Hs
		536773 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI27_HUMAN (1-378): 1.04e-92: 290: 23.56
+	Hs
		1336390 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI39_HUMAN (7-378): 6.84e-96: 298: 24.81
+	Hs
		1318532 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI31_HUMAN (1-425): 1.72e-96: 297: 100.00
+	Hs
		536760 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TRI27_HUMAN (1-378): 1.04e-92: 290: 23.56
+	Hs
		537142 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI27_HUMAN (1-378): 1.04e-92: 290: 23.56
+	Hs
		896370 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM5_HUMAN (1-417): 6.6e-85: 269: 22.00
+	Hs
		896348 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI43_HUMAN (1-388): 6.24e-80: 255: 22.17
+	Hs
		896330 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI50_HUMAN (1-377): 4.55e-79: 254: 17.02
+	Hs
		1318719 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRIM5_HUMAN (1-417): 6.6e-85: 269: 22.00
+	Hs
		135012 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TRI38_HUMAN (1-417): 1.38e-84: 268: 21.68
+	Hs
		135045 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI38_HUMAN (1-417): 1.38e-84: 268: 21.68
+	Hs
		1285831 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI43_HUMAN (1-388): 6.24e-80: 255: 22.17
+	Hs
		1204911 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI50_HUMAN (1-377): 4.55e-79: 254: 17.02
+	Hs
		896398 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI35_HUMAN (3-367): 1.3e-68: 227: 18.92
+	Hs
		1354526 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI10_HUMAN (1-357): 2.16e-75: 244: 27.96
+	Hs
		1377469 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI17_HUMAN (1-378): 1.66e-73: 239: 23.02
+	Hs
		896366 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI34_HUMAN (1-295): 9.49e-66: 219: 27.09
+	Hs
		1313765 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI62_HUMAN (6-378): 8.22e-70: 229: 19.21
+	Hs
		1357712 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI35_HUMAN (3-367): 1.3e-68: 227: 18.92