HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG22 (Q7Z5H3)
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)
Gene: ARHGAP22

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 698
+	Hs
		900637 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SRGP1_HUMAN (97-655): 5.76e-86: 294: 18.37
+	Mm
		1265268 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		SRGP1_MOUSE (59-655): 8.73e-85: 290: 17.55
+	Hs
		900564 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG21_HUMAN (103-682): 1.32e-83: 291: 18.99
+	Hs
		70663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9A_HUMAN (49-665): 1.5e-78: 276: 15.29
+	Hs
		49631 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG10_HUMAN (7-566): 8.92e-81: 275: 17.99
+	Hs
		245183 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OPHN1_HUMAN (13-568): 4.38e-78: 268: 16.61
+	Hs
		901000 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG23_HUMAN (71-641): 2.45e-75: 266: 19.76
+	Hs
		901006 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG20_HUMAN (61-683): 1.09e-74: 263: 16.44
+	Mm
		643072 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		P85A_MOUSE (101-649): 5.31e-76: 260: 15.15
+	Hs
		655297 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		P85A_HUMAN (101-649): 2.79e-75: 258: 14.26
+	Hs
		901048 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG26_HUMAN (12-405): 1.24e-72: 253: 17.85
+	Hs
		900997 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		GMIP_HUMAN (140-561): 4.53e-70: 248: 24.11
+	Hs
		129262 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		P85B_HUMAN (154-649): 4.77e-71: 247: 15.95
+	Hs
		900412 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG01_HUMAN (150-356): 1.9e-69: 235: 29.95
+	Mm
		1125742 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RHG01_MOUSE (150-356): 1.38e-66: 227: 28.50
+	Hs
		900429 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG05_HUMAN (153-364): 1.02e-61: 226: 28.96
+	Mm
		925791 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG01_MOUSE (150-356): 1.38e-66: 227: 28.50
+	Hs
		900426 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ABR_HUMAN (151-336): 3.03e-20: 97.8: 32.80
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (151-355): 2.96e-19: 95.1: 32.41
+	Mm
		925793 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		ABR_MOUSE (151-336): 5.06e-20: 97.1: 32.28