HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: ARHG3 (Q9NR81)
Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)
Gene: ARHGEF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	12221096
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 526
+	Hs
		900636 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG8_HUMAN (6-497): 1.43e-115: 355: 55.58
+	Sc
		419716 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		ROM2_YEAST (61-471): 1.29e-85: 290: 18.91
+	Sp
		1000084 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF1_SCHPO (64-444): 1.66e-75: 261: 21.43
+	Sp
		1000081 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF2_SCHPO (59-452): 2.88e-75: 260: 21.23
+	Sp
		1336810 RHO5_SCHPO (4-193): 1.09e-93: 273: 65.31		RGF1_SCHPO (64-444): 1.66e-75: 261: 21.43
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (78-450): 1.11e-84: 288: 20.00
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (101-450): 2.62e-84: 287: 19.73
+	Hs
		900786 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGQ_HUMAN (11-501): 8.32e-83: 276: 16.45
+	Hs
		166479 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2L_HUMAN (27-522): 1.34e-78: 269: 17.99
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (44-478): 8.26e-80: 269: 17.74
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (54-478): 1.03e-79: 268: 16.71
+	Hs
		167078 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGB_HUMAN (12-525): 6.96e-77: 265: 17.67
+	Hs
		900765 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG1_HUMAN (15-499): 2.3e-77: 262: 18.11
+	Mm
		650205 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RGRF1_MOUSE (102-516): 3.55e-75: 260: 18.22
+	Hs
		900679 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARG28_HUMAN (38-341): 8.5e-74: 256: 21.31
+	Hs
		900612 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGI_HUMAN (59-351): 2.31e-71: 249: 19.94
+	Hs
		900663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGJ_HUMAN (18-444): 5.74e-71: 243: 20.61
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (111-515): 2.33e-61: 220: 18.74
+	Sp
		1000083 RHO1_SCHPO (1-193): 2.83e-94: 274: 66.83		RGF3_SCHPO (119-391): 9.61e-11: 66.6: 26.10
+	Hs
		900417 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		AKP13_HUMAN (96-309): 2.82e-13: 75.1: 22.71