HitPredict

Interactor 1: SCNNB (P51168)
Epithelial sodium channel subunit beta (Beta-ENaC) (ENaC subunit beta) (ENaCB) (Epithelial Na(+) channel subunit beta) (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: SCNN1B

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	39009827
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0035264 - multicellular organism growth
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 400
+	Hs
		902325 SCNNB_HUMAN (1-640): 0: 704: 100.00		ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83
+	Hs
		131833 SCNNB_HUMAN (1-640): 0: 704: 100.00		WWP2_HUMAN (3-220): 6.69e-59: 207: 19.46
+	Hs
		902323 SCNNB_HUMAN (1-640): 0: 704: 100.00		HECW1_HUMAN (14-327): 1.33e-53: 193: 14.29
+	Rn
		788567 SCNNG_RAT (16-625): 0: 566: 36.48		Q4V8H7_RAT (3-386): 1.73e-77: 259: 14.22
+	Hs
		861521 SCNNB_HUMAN (1-640): 0: 704: 100.00		NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00
+	Rn
		788565 SCNNB_RAT (1-640): 0: 684: 83.44		NEDD4_RAT (129-328): 3.13e-22: 100: 11.65
+	Hs
		788545 SCNNA_HUMAN (21-627): 0: 561: 31.54		WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86
+	Hs
		131834 SCNNG_HUMAN (17-626): 0: 571: 35.74		WWP2_HUMAN (3-220): 6.69e-59: 207: 19.46
+	Hs
		902326 SCNNB_HUMAN (1-640): 0: 704: 100.00		NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20
+	Mm
		1298424 SCNNB_MOUSE (1-640): 0: 667: 83.91		NED4L_MOUSE (129-395): 4.78e-24: 106: 11.96
+	Hs
		788540 SCNNA_HUMAN (21-627): 0: 561: 31.54		ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83
+	Mm
		97755 SCNNB_MOUSE (1-640): 0: 667: 83.91		E9PXB7_MOUSE (129-395): 7.94e-23: 102: 12.68
+	Hs
		131774 SCNNA_HUMAN (21-627): 0: 561: 31.54		WWP2_HUMAN (3-220): 6.69e-59: 207: 19.46
+	Mm
		861905 SCNNB_MOUSE (1-640): 0: 667: 83.91		NEDD4_MOUSE (129-328): 8.7e-21: 96.6: 10.44
+	Hs
		788533 SCNNA_HUMAN (21-627): 0: 561: 31.54		HECW1_HUMAN (14-327): 1.33e-53: 193: 14.29
+	Hs
		861522 SCNNG_HUMAN (17-626): 0: 571: 35.74		NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00
+	Rn
		788568 SCNNG_RAT (16-625): 0: 566: 36.48		NEDD4_RAT (129-328): 3.13e-22: 100: 11.65
+	Hs
		788518 SCNNA_HUMAN (21-627): 0: 561: 31.54		NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00
+	Hs
		902341 SCNNG_HUMAN (17-626): 0: 571: 35.74		NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20
+	Hs
		788541 SCNNA_HUMAN (21-627): 0: 561: 31.54		NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20