HitPredict

Interactor 1: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Interactor 2: P121A (Q96HA1)
Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)
Gene: POM121

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005789 - endoplasmic reticulum membrane GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding GO:0031965 - nuclear membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 529 Hs			1 1249
+	Hs
		68012 IMA1_HUMAN (1-529): 6.81e-163: 474: 100.00		P121C_HUMAN (1-1249): 5.62e-81: 292: 94.33
+	Hs
		142603 IMA3_HUMAN (4-529): 4.71e-150: 441: 50.10		P121A_HUMAN (1-1249): 7.12e-87: 310: 100.00
+	Hs
		138745 IMA4_HUMAN (4-529): 2.57e-146: 432: 49.25		P121A_HUMAN (1-1249): 7.12e-87: 310: 100.00
+	Hs
		68006 IMA3_HUMAN (4-529): 4.71e-150: 441: 50.10		P121C_HUMAN (1-1249): 5.62e-81: 292: 94.33
+	Hs
		253676 IMA7_HUMAN (1-528): 2.65e-140: 417: 45.37		P121A_HUMAN (1-1249): 7.12e-87: 310: 100.00
+	Hs
		68005 IMA4_HUMAN (4-529): 2.57e-146: 432: 49.25		P121C_HUMAN (1-1249): 5.62e-81: 292: 94.33
+	Hs
		911339 IMA5_HUMAN (4-528): 4.81e-131: 393: 43.91		P121A_HUMAN (1-1249): 7.12e-87: 310: 100.00
+	Hs
		910949 IMA1_HUMAN (1-529): 6.81e-163: 474: 100.00		POZP3_HUMAN (266-371): 3.15e-26: 109: 75.70
+	Hs
		910821 IMA1_HUMAN (1-529): 6.81e-163: 474: 100.00		NUP98_HUMAN (828-1223): 9.72e-19: 95.1: 19.77
+	Hs
		76104 IMA1_HUMAN (1-529): 6.81e-163: 474: 100.00		B4DET5_HUMAN (12-676): 2.01e-09: 64.1: 8.71
+	Hs
		76076 IMA3_HUMAN (4-529): 4.71e-150: 441: 50.10		B4DET5_HUMAN (12-676): 2.01e-09: 64.1: 8.71
+	Hs
		138638 IMA4_HUMAN (4-529): 2.57e-146: 432: 49.25		NU214_HUMAN (1-848): 1.13e-11: 71.7: 10.12
+	Hs
		76075 IMA4_HUMAN (4-529): 2.57e-146: 432: 49.25		B4DET5_HUMAN (12-676): 2.01e-09: 64.1: 8.71
+	Hs
		911192 IMA5_HUMAN (4-528): 4.81e-131: 393: 43.91		NUP98_HUMAN (828-1223): 9.72e-19: 95.1: 19.77
+	Xl
		909942 IMA5_XENLA (4-529): 1.42e-137: 409: 62.36		Q5EWX9_XENLA (663-1249): 5.34e-12: 72.8: 17.09