HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25659891
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005819 - spindle GO:0005829 - cytosol GO:0008017 - microtubule binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 986
+	Hs
		919917 PLK1_HUMAN (1-603): 0: 619: 100.00		AKP13_HUMAN (37-964): 7.01e-136: 454: 35.95
+	Hs
		919953 PLK1_HUMAN (1-603): 0: 619: 100.00		RGRF1_HUMAN (1-852): 2.09e-93: 325: 11.91
+	Hs
		920298 PLK1_HUMAN (1-603): 0: 619: 100.00		ARHG4_HUMAN (71-645): 4.54e-96: 320: 12.69
+	Hs
		238807 PLK1_HUMAN (1-603): 0: 619: 100.00		KALRN_HUMAN (224-970): 4.71e-87: 309: 12.83
+	Hs
		299527 PLK1_HUMAN (1-603): 0: 619: 100.00		TRIO_HUMAN (224-976): 3.48e-75: 273: 12.76
+	Hs
		919990 PLK1_HUMAN (1-603): 0: 619: 100.00		ITSN1_HUMAN (222-600): 2.11e-69: 255: 22.73
+	Hs
		1148400 KS6A1_HUMAN (1-362): 1.66e-108: 344: 24.87		ARHGC_HUMAN (23-973): 4.79e-101: 349: 16.47
+	Hs
		177381 KS6A1_HUMAN (1-362): 1.66e-108: 344: 24.87		ARHGB_HUMAN (111-917): 1.06e-97: 339: 21.07
+	Hs
		908180 KS6A3_HUMAN (1-326): 4.97e-103: 329: 25.44		ARHGC_HUMAN (23-973): 4.79e-101: 349: 16.47