Protein: AKP13
A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)

Gene: AKP13, AKAP13
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q12802

Gene Ontology (top 5):
GO:0005078 - MAP-kinase scaffold activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005938 - cell cortex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568796

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

7

5

Small-scale

0.950

High

961992

RHOA
Transforming protein RhoA

5

20

Small-scale

0.912

High

725490

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

4

5

High-throughput

0.892

High

729785

1433B
14-3-3 protein beta/alpha

8

20

Small-scale

0.746

High

966250

1433G
14-3-3 protein gamma

6

20

High-throughput

0.737

High

990154

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.729

High

605655

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

6

14

Small-scale

0.726

High

1086360

KPCD1
Serine/threonine-protein kinase D1

1

12

Small-scale

0.724

High

1086390

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.691

High

1049239

1433F
14-3-3 protein eta

4

20

High-throughput

0.691

High

690950

1433T
14-3-3 protein theta

4

20

High-throughput

0.678

High

507175

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

13

High-throughput

0.667

High

1086381

METH
Methionine synthase

3

1

High-throughput

0.667

High

1086368

ARHGI
Rho guanine nucleotide exchange factor 18

1

18

High-throughput

0.665

High

1086382

RTKN
Rhotekin

1

1

Small-scale

0.647

High

603256

KPCA
Protein kinase C alpha type

1

14

Small-scale

0.618

High

666237

KPCL
Protein kinase C eta type

1

12

Small-scale

0.618

High

977962

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1040967

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

17

Small-scale

0.618

High

1086369

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

971453

1433E
14-3-3 protein epsilon

2

10

High-throughput

0.611

High

1086384

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

Small-scale

0.586

High

371884

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.584

High

1086375

ARG28
Rho guanine nucleotide exchange factor 28

1

17

High-throughput

0.575

High

395998

ESR1
Estrogen receptor

1

20

Small-scale

0.573

High

252243

CCNT2
Cyclin-T2

2

4

High-throughput

0.571

High

456710

ANXA2
Annexin A2

2

6

High-throughput

0.571

High

893485

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

17

Small-scale

0.553

High

928832

MYOM2
Myomesin-2

1

9

High-throughput

0.553

High

1086387

CTNL1
Alpha-catulin

1

2

Small-scale

0.552

High

890459

RBP2
E3 SUMO-protein ligase RanBP2

1

10

High-throughput

0.541

High

270803

ROCK2
Rho-associated protein kinase 2

1

13

High-throughput

0.536

High

279148

ULK1
Serine/threonine-protein kinase ULK1

1

13

High-throughput

0.536

High

668570

APC
Adenomatous polyposis coli protein

1

13

High-throughput

0.536

High

692050

MARK3
MAP/microtubule affinity-regulating kinase 3

1

7

High-throughput

0.536

High

884631

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

854019

KI67
Proliferation marker protein Ki-67

1

10

High-throughput

0.515

High

1086362

BAK
Bcl-2 homologous antagonist/killer

1

1

High-throughput

0.515

High

1086364

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

422006

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

533272

THA
Thyroid hormone receptor alpha

1

16

Small-scale

0.501

High

704523

RXRB
Retinoic acid receptor RXR-beta

1

20

Small-scale

0.501

High

1006363

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.501

High

1060601

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.501

High

642544

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.484

High

228240

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.479

High

241525

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

251576

CCNT1
Cyclin-T1

1

4

High-throughput

0.479

High

345724

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

406113

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

459565

PROF1
Profilin-1

1

5

High-throughput

0.479

High

573450

ENPL
Endoplasmin

1

5

High-throughput

0.479

High

643462

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.479

High

730549

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

732300

PRDX2
Peroxiredoxin-2

1

4

High-throughput

0.479

High

786571

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

13

High-throughput

0.479

High

830636

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

919917

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

1086356

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.479

High

1086357

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

18

High-throughput

0.479

High

1086358

CUL3
Cullin-3

1

14

High-throughput

0.479

High

1086359

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1086361

ZYX
Zyxin

1

11

High-throughput

0.479

High

1086365

RN123
E3 ubiquitin-protein ligase RNF123

1

8

High-throughput

0.479

High

1086366

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

1086371

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1086372

TAXB1
Tax1-binding protein 1

1

20

High-throughput

0.479

High

1086373

DDX42
ATP-dependent RNA helicase DDX42

1

1

High-throughput

0.479

High

1086374

SRRM1
Serine/arginine repetitive matrix protein 1

1

15

High-throughput

0.479

High

1086376

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1086377

LNX1
E3 ubiquitin-protein ligase LNX

1

19

Small-scale

0.479

High

1086378

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1086379

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.479

High

1086388

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1086389

FBW1B
F-box/WD repeat-containing protein 11

1

10

High-throughput

0.479

High

992470

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

1086385

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

397945

ANGI
Angiogenin

1

1

High-throughput

0.445

High

1086370

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

1086383

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1086386

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

105832

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

353292

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

1086367

LRC31
Leucine-rich repeat-containing protein 31

1

6

High-throughput

0.437

High

254994

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

1086363

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1086380

GALM
Galactose mutarotase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025