HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.995

The method score is based on:

Property Details
Experiments 9535855, 31871319, 20936779, 19961560, 11130076, 19277120, 25468898, 15548653, 15212766, 25819133, 15143066, 18426980, 12879077, 12650940, 29615491, 24056087, 15187088, 15700267, 21474670, 15673687 and 28 others

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Identification Methods pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach, fluorescent resonance energy transfer
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PBD~Ras, Pkinase~Ras
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 10 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 192
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024