HitPredict

Interactor 1: CASP6 (P55212)
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Gene: CASP6

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11098060
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 293 Hs			1 416
+	Hs
		840111 CASP2_HUMAN (37-291): 7.57e-100: 301: 29.12		TRAF1_HUMAN (1-416): 4.48e-172: 489: 100.00
+	Hs
		1093816 CASP8_HUMAN (5-289): 3.39e-98: 298: 30.20		TRAF1_HUMAN (1-416): 4.48e-172: 489: 100.00
+	Mm
		714568 CASP2_MOUSE (5-291): 1.86e-99: 300: 26.16		TRAF1_MOUSE (1-416): 3.7e-160: 459: 84.38
+	Hs
		1093900 CASPA_HUMAN (12-238): 6.24e-75: 239: 32.75		TRAF1_HUMAN (1-416): 4.48e-172: 489: 100.00
+	Hs
		193009 CFLAR_HUMAN (16-279): 5.5e-71: 228: 22.38		TRAF1_HUMAN (1-416): 4.48e-172: 489: 100.00
+	Hs
		936905 CASP7_HUMAN (33-288): 3.91e-113: 330: 38.28		TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01
+	Mm
		714569 CASP2_MOUSE (5-291): 1.86e-99: 300: 26.16		TRAF2_MOUSE (3-415): 4.36e-127: 378: 37.77
+	Hs
		840110 CASP2_HUMAN (37-291): 7.57e-100: 301: 29.12		TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01
+	Hs
		1090647 CASP8_HUMAN (5-289): 3.39e-98: 298: 30.20		TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01
+	Hs
		712854 CASP1_HUMAN (11-291): 1.32e-98: 296: 23.89		TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01
+	Hs
		1090731 CASPC_HUMAN (48-292): 2.26e-84: 258: 21.65		TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01
+	Hs
		885723 CASP4_HUMAN (5-292): 7.23e-101: 301: 23.30		TRAF6_HUMAN (15-414): 3.23e-103: 317: 22.98
+	Hs
		1132472 CASP8_HUMAN (5-289): 3.39e-98: 298: 30.20		TRAF6_HUMAN (15-414): 3.23e-103: 317: 22.98
+	Mm
		313444 CASP8_MOUSE (4-290): 6.17e-99: 300: 32.48		TRAF6_MOUSE (15-414): 5.28e-101: 312: 22.51
+	Hs
		193008 CFLAR_HUMAN (16-279): 5.5e-71: 228: 22.38		TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01
+	Hs
		840046 CASP3_HUMAN (37-289): 1.1e-110: 323: 41.90		TRAF3_HUMAN (3-262): 8.09e-11: 65.7: 15.77
+	Hs
		840112 CASP2_HUMAN (37-291): 7.57e-100: 301: 29.12		TRAF3_HUMAN (3-262): 8.09e-11: 65.7: 15.77
+	Hs
		193010 CFLAR_HUMAN (16-279): 5.5e-71: 228: 22.38		TRAF3_HUMAN (3-262): 8.09e-11: 65.7: 15.77