HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: PCBP1 (Q15365)
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)
Gene: PCBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.648

Property	Details
Experiments	27684187, 35102251, 16713569
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 356
+	Mm
		888818 SRSF7_MOUSE (7-115): 1.47e-26: 102: 60.55		PCBP1_MOUSE (1-356): 2.47e-107: 320: 100.00
+	Mm
		888801 SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00		PCBP1_MOUSE (1-356): 2.47e-107: 320: 100.00
+	Hs
		853900 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00
+	Hs
		951975 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44
+	Hs
		266997 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44
+	Hs
		853901 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44
+	Mm
		904289 SRSF7_MOUSE (7-115): 1.47e-26: 102: 60.55		HNRPK_MOUSE (7-353): 1.94e-68: 223: 22.51
+	Hs
		903884 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Mm
		904238 SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00		HNRPK_MOUSE (7-353): 1.94e-68: 223: 22.51
+	Mm
		904278 SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65		HNRPK_MOUSE (7-353): 1.94e-68: 223: 22.51
+	Mm
		192620 SRSF5_MOUSE (10-112): 1.98e-24: 97: 44.34		HNRPK_MOUSE (7-353): 1.94e-68: 223: 22.51
+	Mm
		904361 SRS10_MOUSE (1-164): 2.25e-24: 96.6: 32.54		HNRPK_MOUSE (7-353): 1.94e-68: 223: 22.51
+	Hs
		853838 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		HNRPK_HUMAN (7-353): 1.94e-68: 223: 22.51
+	Hs
		128192 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		IF2B3_HUMAN (1-187): 4.45e-25: 107: 25.13
+	Dm
		2536 Q9VYD8_DROME (7-80): 2.07e-25: 97: 70.27		NOVA_DROME (13-183): 3.27e-14: 75.9: 31.32
+	Hs
		1028764 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		FUBP1_HUMAN (224-352): 2.53e-13: 72.9: 22.48
+	Hs
		853956 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		FUBP2_HUMAN (237-352): 3.22e-13: 72.5: 26.72
+	Hs
		884293 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		PCBP3_HUMAN (1-85): 2.23e-11: 66.4: 28.74
+	Hs
		952198 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		IF2B2_HUMAN (237-350): 8.67e-09: 59: 17.39
+	Zm
		20647 A0A1D6HMW8_MAIZE (10-85): 2.32e-24: 96.3: 36.70		B6U784_MAIZE (10-63): 2.02e-09: 61: 30.36