HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: PKHG6 (Q3KR16)
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
Gene: PLEKHG6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 790
+	Hs
		977711 ACTA_HUMAN (2-375): 0: 591: 94.12		PKHG6_HUMAN (1-790): 1.03e-180: 539: 100.00
+	Hs
		1247508 POTEE_HUMAN (1-375): 0: 736: 92.00		FGD4_HUMAN (59-692): 1.43e-99: 327: 14.92
+	Hs
		1247538 POTEE_HUMAN (1-375): 0: 736: 92.00		PKHG1_HUMAN (45-746): 6.78e-87: 302: 15.93
+	Hs
		1247506 POTEE_HUMAN (1-375): 0: 736: 92.00		Q96D37_HUMAN (99-690): 1.41e-87: 295: 15.02
+	Hs
		584560 POTEE_HUMAN (1-375): 0: 736: 92.00		VAV_HUMAN (99-690): 5.99e-87: 295: 15.02
+	Hs
		584551 ACTBL_HUMAN (2-375): 0: 735: 91.71		VAV_HUMAN (99-690): 5.99e-87: 295: 15.02
+	Hs
		177386 POTEE_HUMAN (1-375): 0: 736: 92.00		ARHGB_HUMAN (22-750): 1.28e-81: 287: 17.48
+	Hs
		1247520 POTEE_HUMAN (1-375): 0: 736: 92.00		ECT2_HUMAN (77-645): 5.33e-81: 280: 19.26
+	Hs
		1154094 ACTBL_HUMAN (2-375): 0: 735: 91.71		ITSN1_HUMAN (60-568): 2.74e-78: 278: 18.72
+	Mm
		993100 ACTG_MOUSE (1-375): 0: 601: 98.93		PKHG5_MOUSE (2-774): 1.67e-114: 374: 32.77
+	Hs
		953045 ACTB_HUMAN (1-375): 0: 603: 100.00		FGD4_HUMAN (59-692): 1.43e-99: 327: 14.92
+	Hs
		584508 ACTA_HUMAN (2-375): 0: 591: 94.12		VAV_HUMAN (99-690): 5.99e-87: 295: 15.02
+	Hs
		952844 ACTB_HUMAN (1-375): 0: 603: 100.00		ITSN1_HUMAN (60-568): 2.74e-78: 278: 18.72
+	Hs
		993189 ACTG_HUMAN (1-375): 0: 601: 98.93		ITSN1_HUMAN (60-568): 2.74e-78: 278: 18.72
+	Hs
		995825 ACTC_HUMAN (2-375): 0: 592: 94.12		ECT2_HUMAN (77-645): 5.33e-81: 280: 19.26
+	Hs
		996460 ACTS_HUMAN (2-375): 0: 592: 93.58		ITSN1_HUMAN (60-568): 2.74e-78: 278: 18.72