HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: MILK2 (Q8IY33)
MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)
Gene: MICALL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36307841
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 904
+	Mm
		953241 ACTB_MOUSE (1-375): 0: 603: 100.00		MILK2_MOUSE (1-888): 5.56e-77: 273: 42.87
+	Hs
		773720 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN2_HUMAN (2-220): 5.56e-66: 240: 28.31
+	Hs
		224675 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN4_HUMAN (2-220): 1.07e-64: 236: 27.85
+	Hs
		540248 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB1_HUMAN (2-216): 5.14e-61: 228: 29.30
+	Mm
		977883 ACTA_MOUSE (2-375): 0: 591: 94.12		ACTN2_MOUSE (2-220): 5.56e-66: 240: 28.31
+	Hs
		224687 ACTC_HUMAN (2-375): 0: 592: 94.12		ACTN4_HUMAN (2-220): 1.07e-64: 236: 27.85
+	Hs
		224688 ACTS_HUMAN (2-375): 0: 592: 93.58		ACTN4_HUMAN (2-220): 1.07e-64: 236: 27.85
+	Hs
		952750 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB2_HUMAN (2-219): 2.24e-59: 224: 30.28
+	Hs
		993135 ACTG_HUMAN (1-375): 0: 601: 98.93		SPTB2_HUMAN (2-219): 2.24e-59: 224: 30.28
+	Dm
		534344 ACT5_DROME (2-375): 0: 596: 95.99		ACTN_DROME (1-220): 7.16e-62: 228: 25.10
+	Mm
		993092 ACTG_MOUSE (1-375): 0: 601: 98.93		SMCA4_MOUSE (316-894): 2.4e-58: 220: 12.33
+	Hs
		995543 ACTC_HUMAN (2-375): 0: 592: 94.12		SPTB2_HUMAN (2-219): 2.24e-59: 224: 30.28
+	Hs
		903297 ACTB_HUMAN (1-375): 0: 603: 100.00		SMCA4_HUMAN (316-894): 1.17e-55: 212: 12.33
+	Hs
		903306 ACTG_HUMAN (1-375): 0: 601: 98.93		SMCA4_HUMAN (316-894): 1.17e-55: 212: 12.33
+	Hs
		953039 ACTB_HUMAN (1-375): 0: 603: 100.00		CLMN_HUMAN (3-745): 1.44e-53: 204: 16.32
+	Hs
		903307 ACTC_HUMAN (2-375): 0: 592: 94.12		SMCA4_HUMAN (316-894): 1.17e-55: 212: 12.33
+	Hs
		903308 ACTS_HUMAN (2-375): 0: 592: 93.58		SMCA4_HUMAN (316-894): 1.17e-55: 212: 12.33
+	Oc
		996588 ACTS_RABIT (2-375): 0: 592: 93.58		Q07931_RABIT (2-132): 1.39e-57: 201: 40.46
+	Sp
		151141 ACT_SCHPO (1-375): 0: 592: 90.40		AIN1_SCHPO (1-116): 2.69e-50: 190: 37.61
+	Hs
		174729 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTN2_HUMAN (2-106): 1.23e-21: 103: 53.33