HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: PACE1 (Q8IZE3)
Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3)
Gene: SCYL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005829 - cytosol GO:0030027 - lamellipodium
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 742
+	Hs
		692037 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		580880 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		692132 RHOJ_HUMAN (2-190): 2.65e-80: 239: 60.32		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		692023 RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		692041 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		692024 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		988474 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		MARK2_HUMAN (16-672): 6.53e-114: 364: 11.48
+	Hs
		692027 RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32		MARK3_HUMAN (2-590): 1.77e-122: 385: 11.03
+	Hs
		581132 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		MARK2_HUMAN (16-672): 6.53e-114: 364: 11.48
+	Hs
		1270523 RHOJ_HUMAN (2-190): 2.65e-80: 239: 60.32		MARK2_HUMAN (16-672): 6.53e-114: 364: 11.48
+	Hs
		953523 RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00		MARK2_HUMAN (16-672): 6.53e-114: 364: 11.48
+	Hs
		1015546 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		MARK2_HUMAN (16-672): 6.53e-114: 364: 11.48
+	Hs
		581029 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		KCC2G_HUMAN (5-500): 1.22e-113: 356: 12.46
+	Hs
		955479 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		SCYL1_HUMAN (13-423): 7.12e-115: 367: 27.44
+	Hs
		581030 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		KCC2D_HUMAN (5-516): 1.39e-113: 354: 12.43
+	Hs
		955318 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		MARK2_HUMAN (16-672): 6.53e-114: 364: 11.48
+	Hs
		955482 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		MARK4_HUMAN (16-579): 1.79e-114: 364: 10.99
+	Hs
		1242044 RHOJ_HUMAN (2-190): 2.65e-80: 239: 60.32		SCYL2_HUMAN (14-456): 1.9e-86: 294: 19.37
+	Hs
		1015531 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		SCYL2_HUMAN (14-456): 1.9e-86: 294: 19.37
+	Hs
		962170 RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32		SCYL2_HUMAN (14-456): 1.9e-86: 294: 19.37