HitPredict

Interactor 1: CXCR4 (P61073)
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
Gene: CXCR4

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007420 - brain development GO:0030335 - positive regulation of cell migration
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 352 Hs			1 3056
+	Hs
		886050 CXCR3_HUMAN (10-350): 1.54e-83: 259: 34.01		ATM_HUMAN (1-3056): 0: 3845: 100.00
+	Hs
		1101478 GPR17_HUMAN (23-346): 5.12e-82: 255: 24.92		ATM_HUMAN (1-3056): 0: 3845: 100.00
+	Hs
		771117 APJ_HUMAN (14-345): 1.56e-69: 223: 25.93		ATM_HUMAN (1-3056): 0: 3845: 100.00
+	Hs
		770852 OPRM_HUMAN (3-352): 1.14e-68: 222: 21.05		ATM_HUMAN (1-3056): 0: 3845: 100.00
+	Hs
		669316 ACKR3_HUMAN (41-310): 6.48e-47: 164: 31.05		ATM_HUMAN (1-3056): 0: 3845: 100.00
+	Hs
		638408 FPR1_HUMAN (36-319): 6.48e-39: 143: 32.78		ATM_HUMAN (1-3056): 0: 3845: 100.00
+	Hs
		1101481 GPR17_HUMAN (23-346): 5.12e-82: 255: 24.92		ATR_HUMAN (1223-3056): 0: 1201: 20.34
+	Hs
		770853 OPRM_HUMAN (3-352): 1.14e-68: 222: 21.05		ATR_HUMAN (1223-3056): 0: 1201: 20.34
+	Hs
		839218 CXCR4_HUMAN (1-336): 5.07e-84: 260: 100.00		MTOR_HUMAN (1846-3055): 0: 836: 16.65
+	Hs
		839256 GPR17_HUMAN (23-346): 5.12e-82: 255: 24.92		MTOR_HUMAN (1846-3055): 0: 836: 16.65
+	Hs
		771099 APJ_HUMAN (14-345): 1.56e-69: 223: 25.93		MTOR_HUMAN (1846-3055): 0: 836: 16.65
+	Hs
		638394 FPR1_HUMAN (36-319): 6.48e-39: 143: 32.78		MTOR_HUMAN (1846-3055): 0: 836: 16.65
+	Hs
		1008126 GPR17_HUMAN (23-346): 5.12e-82: 255: 24.92		PRKDC_HUMAN (2005-3056): 2.08e-153: 540: 17.20
+	Hs
		458375 ADRB2_HUMAN (6-341): 1.02e-70: 227: 17.07		PRKDC_HUMAN (2005-3056): 2.08e-153: 540: 17.20
+	Hs
		638407 FPR1_HUMAN (36-319): 6.48e-39: 143: 32.78		PRKDC_HUMAN (2005-3056): 2.08e-153: 540: 17.20
+	Hs
		839142 CXCR4_HUMAN (1-336): 5.07e-84: 260: 100.00		PK3CB_HUMAN (2385-3011): 9.74e-98: 345: 13.76
+	Hs
		877415 CXCR4_HUMAN (1-336): 5.07e-84: 260: 100.00		PK3CG_HUMAN (2437-2965): 4.27e-88: 316: 16.14
+	Mm
		1000496 CXCR4_MOUSE (3-336): 1.38e-79: 249: 88.79		PK3CG_MOUSE (2446-2965): 4.71e-87: 313: 16.04