HitPredict

Interactor 1: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: ZN517 (Q6ZMY9)
Zinc finger protein 517
Gene: ZNF517

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 4655 Hs			1 492
+	Hs
		200250 LRP2_HUMAN (1-4655): 0: 3803: 100.00		ZN264_HUMAN (54-163): 1.93e-11: 68.2: 6.36
+	Hs
		1168507 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		ZN517_HUMAN (1-492): 0: 590: 100.00
+	Hs
		1223925 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		ZNF34_HUMAN (1-479): 0: 588: 35.99
+	Hs
		254273 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		ZNF34_HUMAN (1-479): 0: 588: 35.99
+	Hs
		1168513 LRP1B_HUMAN (4-204): 6.71e-09: 64.9: 16.16		ZN517_HUMAN (1-492): 0: 590: 100.00
+	Hs
		254278 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		ZN383_HUMAN (213-492): 1.72e-146: 429: 46.85
+	Hs
		270315 LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30		ZN383_HUMAN (213-492): 1.72e-146: 429: 46.85
+	Hs
		258331 LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42		ZN383_HUMAN (213-492): 1.72e-146: 429: 46.85
+	Hs
		1205167 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		Z354C_HUMAN (65-346): 3.8e-76: 250: 32.16
+	Hs
		1241513 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		ZN485_HUMAN (178-427): 2.35e-76: 248: 47.81
+	Hs
		254270 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		Z354C_HUMAN (65-346): 3.8e-76: 250: 32.16
+	Hs
		1269026 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		ZN331_HUMAN (171-390): 7.29e-50: 178: 43.89
+	Hs
		1083635 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		ZNF74_HUMAN (46-232): 1.94e-44: 167: 19.68
+	Hs
		254295 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		ZN331_HUMAN (171-390): 7.29e-50: 178: 43.89
+	Hs
		254261 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		ZNF74_HUMAN (46-232): 1.94e-44: 167: 19.68
+	Hs
		1343927 LRP1B_HUMAN (4-204): 6.71e-09: 64.9: 16.16		ZN331_HUMAN (171-390): 7.29e-50: 178: 43.89
+	Hs
		200259 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		ZN264_HUMAN (54-163): 1.93e-11: 68.2: 6.36