HitPredict

Interactor 1: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: JIP1 (Q9UQF2)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: MAPK8IP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.609

Property	Details
Experiments	10827173, 12508107
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4655 Hs			1 711
+	Mm
		57563 LRP2_MOUSE (22-4655): 0: 3723: 76.66		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Hs
		957621 LRP2_HUMAN (1-4655): 0: 3803: 100.00		ANS1B_HUMAN (424-700): 7.53e-71: 253: 18.60
+	Hs
		957599 LRP2_HUMAN (1-4655): 0: 3803: 100.00		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Mm
		57562 LRP2_MOUSE (22-4655): 0: 3723: 76.66		JIP2_MOUSE (25-274): 1.81e-66: 236: 28.63
+	Hs
		253552 LRP2_HUMAN (1-4655): 0: 3803: 100.00		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69
+	Hs
		957612 LRP2_HUMAN (1-4655): 0: 3803: 100.00		ARH_HUMAN (548-706): 2.74e-37: 143: 20.50
+	Rn
		88518 LRP2_RAT (1-4655): 0: 3738: 76.27		ARH_RAT (548-696): 3.42e-34: 134: 20.53
+	Mm
		57558 LRP2_MOUSE (22-4655): 0: 3723: 76.66		ARH_MOUSE (548-696): 2.95e-36: 140: 20.53
+	Mm
		1257662 LRP4_MOUSE (180-440): 7.8e-20: 101: 21.12		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Mm
		1266182 LRP8_MOUSE (2623-2869): 2.33e-11: 72.6: 16.36		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Mm
		69888 B1AXJ3_MOUSE (3424-3628): 4.43e-11: 71.8: 12.50		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Mm
		1265300 LRP1_MOUSE (3672-3974): 3.08e-09: 66: 10.16		JIP1_MOUSE (1-711): 0: 995: 93.40
+	Hs
		1048463 LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92		JIP1_HUMAN (1-711): 0: 955: 100.00
+	Hs
		1032902 LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92		JIP2_HUMAN (25-273): 1.95e-67: 239: 31.92
+	Mm
		1266181 LRP8_MOUSE (2623-2869): 2.33e-11: 72.6: 16.36		JIP2_MOUSE (25-274): 1.81e-66: 236: 28.63
+	Mm
		69886 B1AXJ3_MOUSE (3424-3628): 4.43e-11: 71.8: 12.50		JIP2_MOUSE (25-274): 1.81e-66: 236: 28.63
+	Mm
		1265299 LRP1_MOUSE (3672-3974): 3.08e-09: 66: 10.16		JIP2_MOUSE (25-274): 1.81e-66: 236: 28.63
+	Hs
		253558 LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69
+	Hs
		351073 LDLR_HUMAN (927-1187): 1.96e-15: 86: 17.65		ARH_HUMAN (548-706): 2.74e-37: 143: 20.50
+	Hs
		253555 LRP1_HUMAN (1102-1387): 4.45e-09: 65.6: 13.59		CAPON_HUMAN (545-707): 1.47e-38: 151: 20.69