HitPredict

Interactor 1: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Interactor 2: CABL2 (Q9BTV7)
CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2)
Gene: CABLES2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	11955625, 25852190, 32707033, 36736316, 23602568, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0007049 - cell cycle GO:0051301 - cell division GO:0051726 - regulation of cell cycle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 292 Hs			1 478
+	Hs
		960117 CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30		CABL2_HUMAN (34-478): 0: 683: 100.00
+	Hs
		841310 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		CABL2_HUMAN (34-478): 0: 683: 100.00
+	Hs
		960313 CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00		CABL1_HUMAN (118-476): 0: 563: 64.09
+	Hs
		841276 CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24		CABL1_HUMAN (118-476): 0: 563: 64.09
+	Dm
		54140 CDK5_DROME (1-288): 1.68e-132: 378: 79.17		A1Z9G1_DROME (173-477): 6.59e-145: 433: 38.28
+	Dm
		54139 CDK2_DROME (1-289): 8.92e-127: 365: 49.48		A1Z9G1_DROME (173-477): 6.59e-145: 433: 38.28
+	Dm
		820762 CDK5_DROME (1-288): 1.68e-132: 378: 79.17		Q9Y138_DROME (173-455): 1.54e-130: 395: 37.78
+	Dm
		618492 CDK2_DROME (1-289): 8.92e-127: 365: 49.48		Q9Y138_DROME (173-455): 1.54e-130: 395: 37.78