HitPredict

Interactor 1: STX1B (P61266)
Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)
Gene: STX1B

Interactor 2: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	32296183, 12093152, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006887 - exocytosis and 2 others more... GO:0016020 - membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 116
+	Hs
		662336 STX1B_HUMAN (1-288): 1.24e-84: 257: 100.00		VAMP1_HUMAN (5-116): 1.61e-30: 107: 74.36
+	Mm
		960324 STX1B_MOUSE (1-288): 1.24e-84: 257: 100.00		VAMP2_MOUSE (25-116): 5.69e-26: 95.1: 100.00
+	Rn
		746118 STX1A_RAT (1-287): 1.61e-78: 241: 81.94		VAMP7_RAT (3-97): 9.56e-31: 110: 32.00
+	Rn
		746117 STX1A_RAT (1-287): 1.61e-78: 241: 81.94		VAMP1_RAT (5-116): 5.72e-30: 105: 73.50
+	Hs
		908014 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP7_HUMAN (3-96): 2.55e-30: 109: 31.31
+	Hs
		662345 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP1_HUMAN (5-116): 1.61e-30: 107: 74.36
+	Hs
		328656 STX1B_HUMAN (1-288): 1.24e-84: 257: 100.00		VAMP5_HUMAN (28-98): 2.31e-22: 85.9: 39.44
+	Hs
		746190 STX2_HUMAN (1-287): 3.91e-80: 245: 64.81		VAMP2_HUMAN (25-116): 5.69e-26: 95.1: 100.00
+	Hs
		746200 STX2_HUMAN (1-287): 3.91e-80: 245: 64.81		VAMP3_HUMAN (26-98): 5.64e-25: 92.4: 91.78
+	Mm
		204922 STX1A_MOUSE (1-287): 1.15e-78: 241: 82.29		VAMP2_MOUSE (25-116): 5.69e-26: 95.1: 100.00
+	Rn
		746110 STX1A_RAT (1-287): 1.61e-78: 241: 81.94		VAMP2_RAT (25-116): 5.69e-26: 95.1: 100.00
+	Hs
		746221 STX2_HUMAN (1-287): 3.91e-80: 245: 64.81		VAMP8_HUMAN (20-99): 1.87e-24: 90.8: 32.50
+	Hs
		278503 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP4_HUMAN (18-99): 3.79e-27: 98.9: 35.37
+	Rn
		746121 STX1A_RAT (1-287): 1.61e-78: 241: 81.94		VAMP8_RAT (21-95): 1.13e-24: 91.6: 34.67
+	Hs
		989336 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP2_HUMAN (25-116): 5.69e-26: 95.1: 100.00
+	Hs
		328635 STX2_HUMAN (1-287): 3.91e-80: 245: 64.81		VAMP5_HUMAN (28-98): 2.31e-22: 85.9: 39.44
+	Hs
		1154625 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP3_HUMAN (26-98): 5.64e-25: 92.4: 91.78
+	Hs
		1159628 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP8_HUMAN (20-99): 1.87e-24: 90.8: 32.50
+	Hs
		328672 STX1A_HUMAN (1-286): 1.75e-76: 236: 81.88		VAMP5_HUMAN (28-98): 2.31e-22: 85.9: 39.44
+	Dm
		121793 STX1A_DROME (2-282): 4.04e-72: 225: 69.01		M9PGI6_DROME (1-112): 1.01e-24: 94.7: 20.54