HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	26496610, 32707033, 36736316, 33961781, 35271311, 36931259, 15324660, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 619
+	Hs
		972164 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Hs
		971928 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		966796 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		971778 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		DCLK2_HUMAN (22-618): 2.43e-140: 428: 19.07
+	Mm
		972250 1433E_MOUSE (1-244): 2.03e-141: 398: 63.53		DCLK2_MOUSE (22-618): 1.07e-138: 423: 18.91
+	Hs
		966608 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		DCLK2_HUMAN (22-618): 2.43e-140: 428: 19.07
+	Hs
		176814 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		DCLK1_HUMAN (22-618): 9.51e-135: 412: 16.72
+	Hs
		176811 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		DCLK1_HUMAN (22-618): 9.51e-135: 412: 16.72
+	Mm
		972321 1433E_MOUSE (1-244): 2.03e-141: 398: 63.53		DCLK1_MOUSE (22-618): 5.38e-132: 406: 17.05
+	Hs
		972086 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		PAK5_HUMAN (4-617): 1.77e-129: 398: 20.21
+	At
		1379653 14337_ARATH (3-244): 3.2e-142: 400: 60.25		CIPKC_ARATH (336-618): 2.04e-128: 388: 26.67
+	At
		840534 14333_ARATH (1-244): 4.42e-142: 400: 61.79		CIPKC_ARATH (336-618): 2.04e-128: 388: 26.67
+	At
		1030913 14332_ARATH (4-244): 1.4e-141: 398: 61.32		CIPKC_ARATH (336-618): 2.04e-128: 388: 26.67
+	Hs
		966267 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		PAK2_HUMAN (106-617): 4.89e-129: 391: 24.33
+	Hs
		966265 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		PAK1_HUMAN (96-617): 1.66e-125: 382: 23.83
+	Dm
		94942 1433E_DROME (1-243): 1.59e-140: 396: 63.37		E1JGN0_DROME (203-617): 1.35e-110: 359: 22.70
+	At
		840482 14333_ARATH (1-244): 4.42e-142: 400: 61.79		M3K2_ARATH (294-617): 2.17e-113: 354: 42.77
+	Xl
		237423 O57468_XENLA (1-244): 4.27e-141: 397: 63.12		Q804T2_XENLA (293-618): 5.46e-110: 348: 27.96
+	Hs
		971475 1433E_HUMAN (1-244): 2.03e-141: 398: 63.53		M3K1_HUMAN (351-613): 5.84e-51: 192: 42.13
+	Hs
		966269 1433G_HUMAN (1-247): 3.17e-139: 392: 100.00		M3K1_HUMAN (351-613): 5.84e-51: 192: 42.13