HitPredict

Interactor 1: LSM6 (P62312)
U6 snRNA-associated Sm-like protein LSm6
Gene: LSM6

Interactor 2: SART3 (Q15020)
Spliceosome associated factor 3, U4/U6 recycling protein (Squamous cell carcinoma antigen recognized by T-cells 3) (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)
Gene: SART3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	28514442, 33961781, 27173435, 19615732, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 80 Hs			1 963
+	Hs
		1137209 LSM4_HUMAN (8-80): 5.84e-33: 112: 27.03		SART3_HUMAN (1-963): 0: 646: 100.00
+	Hs
		973917 RUXF_HUMAN (5-74): 6.05e-31: 105: 48.57		SART3_HUMAN (1-963): 0: 646: 100.00
+	Hs
		1137203 LSM2_HUMAN (10-80): 3.62e-20: 78.4: 27.03		SART3_HUMAN (1-963): 0: 646: 100.00
+	Hs
		974040 RUXF_HUMAN (5-74): 6.05e-31: 105: 48.57		CRNL1_HUMAN (36-683): 9.92e-111: 363: 14.49
+	Hs
		1419986 LSM2_HUMAN (10-80): 3.62e-20: 78.4: 27.03		CRNL1_HUMAN (36-683): 9.92e-111: 363: 14.49
+	Ce
		1164852 Q95XN6_CAEEL (4-78): 3.86e-30: 103: 81.33		SART3_CAEEL (73-770): 1.68e-98: 330: 21.42
+	Ce
		759803 RUXF_CAEEL (2-78): 2.27e-29: 101: 38.96		SART3_CAEEL (73-770): 1.68e-98: 330: 21.42
+	Ce
		1164846 LSM4_CAEEL (8-80): 2.85e-28: 99.6: 28.38		SART3_CAEEL (73-770): 1.68e-98: 330: 21.42
+	Sc
		933155 RUXF_YEAST (2-75): 1.15e-26: 94.6: 40.00		CLF1_YEAST (48-658): 1.82e-73: 258: 13.68
+	Sc
		847845 SMD3_YEAST (8-77): 3.89e-23: 86.1: 24.29		CLF1_YEAST (48-658): 1.82e-73: 258: 13.68
+	Sc
		813363 RUXF_YEAST (2-75): 1.15e-26: 94.6: 40.00		PRP39_YEAST (130-596): 3.45e-67: 239: 13.25
+	Sc
		813357 SMD3_YEAST (8-77): 3.89e-23: 86.1: 24.29		PRP39_YEAST (130-596): 3.45e-67: 239: 13.25
+	Hs
		321707 LSM4_HUMAN (8-80): 5.84e-33: 112: 27.03		PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42
+	Hs
		321486 LSM6_HUMAN (1-80): 4e-33: 110: 100.00		PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42
+	Hs
		321483 RUXF_HUMAN (5-74): 6.05e-31: 105: 48.57		PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42
+	Zm
		8309 B6UER1_MAIZE (10-80): 7.11e-21: 79.9: 29.73		A0A1D6ELI3_MAIZE (697-948): 2.23e-55: 207: 25.28
+	Hs
		321701 LSM2_HUMAN (10-80): 3.62e-20: 78.4: 27.03		PRP6_HUMAN (33-561): 1.08e-50: 195: 13.42
+	Dm
		1480002 Q9VKW8_DROME (8-80): 4.9e-33: 112: 27.03		RNP4F_DROME (791-895): 2.75e-16: 85.9: 40.00
+	Dm
		1489789 Q9W2P5_DROME (4-80): 4.71e-29: 100: 85.71		RNP4F_DROME (791-895): 2.75e-16: 85.9: 40.00
+	Hs
		974053 RUXF_HUMAN (5-74): 6.05e-31: 105: 48.57		SYF1_HUMAN (110-370): 1.23e-14: 80.5: 13.01