HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 126
+	Hs
		918303 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241509 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		707596 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		886089 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		975314 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		1087483 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918772 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1079994 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1080205 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		918389 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241535 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		203602 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		1274453 ASH1L_HUMAN (3266-3968): 1.46e-72: 275: 14.78		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Sp
		223810 CLR4_SCHPO (3556-3968): 1.26e-79: 275: 16.52		H2B1_SCHPO (4-125): 1.24e-45: 145: 70.49
+	Hs
		331768 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		331825 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Sc
		355890 SET1_YEAST (3466-3969): 6.89e-73: 270: 21.67		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Hs
		1087385 NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918663 NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707738 NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41