Protein: IQEC1
IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)

Gene: IQEC1, IQSEC1
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q6DN90

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0008021 - synaptic vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1207205

IQEC2
IQ motif and SEC7 domain-containing protein 2

1

8

High-throughput

0.665

High

896792

DYN2
Dynamin-2

1

1

High-throughput

0.665

High

975090

ARF6
ADP-ribosylation factor 6

1

16

High-throughput

0.618

High

1231870

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

3

7

High-throughput

0.604

High

1101838

SKP2
S-phase kinase-associated protein 2

2

0

High-throughput

0.602

High

1231836

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.602

High

191342

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

2

1

High-throughput

0.601

High

904832

MECP2
Methyl-CpG-binding protein 2

2

1

High-throughput

0.601

High

1231878

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.553

High

764371

CTNA1
Catenin alpha-1

1

1

Small-scale

0.552

High

1211421

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.549

High

177240

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

2

High-throughput

0.536

High

210192

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

274626

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.536

High

922318

LIMK2
LIM domain kinase 2

1

2

High-throughput

0.536

High

966465

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

1178838

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.536

High

1231846

LRC25
Leucine-rich repeat-containing protein 25

1

2

High-throughput

0.536

High

1231858

EFMT3
EEF1A lysine methyltransferase 3

1

3

High-throughput

0.536

High

1231861

ANM6
Protein arginine N-methyltransferase 6

1

6

High-throughput

0.536

High

1231872

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

3

High-throughput

0.536

High

1231874

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

High-throughput

0.536

High

1231884

LATS2
Serine/threonine-protein kinase LATS2

1

2

High-throughput

0.536

High

1231889

HSPB8
Heat shock protein beta-8

1

1

High-throughput

0.536

High

1231893

ASB4
Ankyrin repeat and SOCS box protein 4

1

7

High-throughput

0.536

High

160718

TOR1A
Torsin-1A

1

3

High-throughput

0.534

High

241991

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.534

High

1123673

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.534

High

893493

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

3

Small-scale

0.533

High

830913

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

905595

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.515

High

422317

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

488496

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

High-throughput

0.515

High

791459

SYUA
Alpha-synuclein

1

5

High-throughput

0.515

High

1231873

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.515

High

261508

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

296788

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

469102

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.513

High

1034750

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1231845

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

0

High-throughput

0.513

High

1231857

IRF7
Interferon regulatory factor 7

1

0

High-throughput

0.513

High

1231862

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1231880

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.513

High

361277

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.511

High

1096046

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.511

High

47343

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.493

High

843660

HD
Huntingtin

1

0

High-throughput

0.493

High

890001

PSN1
Presenilin-1

1

0

High-throughput

0.493

High

927353

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

1160487

SMN
Survival motor neuron protein

1

0

High-throughput

0.493

High

1231838

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.493

High

1231851

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.493

High

1231856

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1231867

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.493

High

317338

ACL6B
Actin-like protein 6B

1

2

High-throughput

0.489

High

653724

PROZ
Vitamin K-dependent protein Z

1

1

High-throughput

0.489

High

848653

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

1231840

ST32C
Serine/threonine-protein kinase 32C

1

1

High-throughput

0.489

High

1231848

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1231869

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.489

High

1231886

FBLN5
Fibulin-5

1

1

High-throughput

0.489

High

172941

XPO1
Exportin-1

1

3

High-throughput

0.479

High

372290

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

400993

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

965021

WDR5
WD repeat-containing protein 5

1

3

Small-scale

0.479

High

978084

RHOB
Rho-related GTP-binding protein RhoB

1

11

High-throughput

0.479

High

1004703

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1045401

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1091516

DLG1
Disks large homolog 1

1

6

Small-scale

0.479

High

1107823

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1113388

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1118060

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

1231843

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1231847

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

1231854

ASB11
Ankyrin repeat and SOCS box protein 11

1

7

High-throughput

0.479

High

1231859

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

High-throughput

0.479

High

1231864

ALS2
Alsin

1

1

High-throughput

0.479

High

1231866

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

1231868

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

1231879

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1231881

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1231882

CPAP
Centrosomal P4.1-associated protein

1

1

High-throughput

0.479

High

1231888

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

3494

A0A0S2Z5Q7
Alsin Rho guanine nucleotide exchange factor ALS2

1

2

High-throughput

0.470

High

387430

APOE
Apolipoprotein E

1

0

High-throughput

0.460

High

879187

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

1143949

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

1178197

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1231835

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1231885

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1231890

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

1231894

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

1231871

SYT3
Synaptotagmin-3

1

1

Small-scale

0.457

High

537338

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.445

High

679350

DNJB2
DnaJ homolog subfamily B member 2

1

3

High-throughput

0.445

High

844801

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

934741

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

938108

ANM2
Protein arginine N-methyltransferase 2

1

6

High-throughput

0.445

High

943965

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.445

High

1226864

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

1231839

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

2

High-throughput

0.445

High

1231852

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.445

High

1231863

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

6

High-throughput

0.445

High

1231865

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

9

High-throughput

0.445

High

1231875

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.445

High

1231876

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

High-throughput

0.445

High

1231891

TRAK1
Trafficking kinesin-binding protein 1

1

1

High-throughput

0.445

High

848273

MAGA3
Melanoma-associated antigen 3

1

2

High-throughput

0.439

High

174531

TRI66
Tripartite motif-containing protein 66

1

4

High-throughput

0.437

High

293842

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

1231837

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1231877

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.437

High

756240

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.426

High

1063052

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.426

High

1199519

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1231842

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

0

High-throughput

0.426

High

1231887

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.426

High

1231892

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

255074

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.407

High

1231844

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.407

High

1231850

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

936558

AF17
Protein AF-17

2

0

High-throughput

0.328

High

1204648

TFDP3
Transcription factor Dp family member 3

2

0

High-throughput

0.318

High

249293

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.279

Low

472184

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

690028

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

986908

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

0

High-throughput

0.279

Low

1210837

DACT2
Dapper homolog 2

1

0

High-throughput

0.279

Low

1231841

FA83A
Protein FAM83A

1

0

High-throughput

0.279

Low

1231853

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.279

Low

1231855

BSND
Barttin

1

0

High-throughput

0.279

Low

1231860

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1231883

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

369685

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.268

Low

991862

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1231849

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025