HitPredict

Interactor 1: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Interactor 2: BIG1 (Q9Y6D6)
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)
Gene: ARFGEF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35844135
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arf~DCB, Arf~Sec7
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 1849
+	Dm
		958896 ARF1_DROME (2-175): 1.28e-64: 197: 70.12		Q9VJW1_DROME (6-1836): 0: 1557: 55.56
+	Hs
		1015142 ARF5_HUMAN (2-173): 5.22e-69: 208: 65.12		PSD3_HUMAN (206-1019): 5.37e-97: 341: 14.60
+	Hs
		975280 ARF6_HUMAN (1-175): 2.77e-65: 199: 100.00		PSD3_HUMAN (206-1019): 5.37e-97: 341: 14.60
+	Hs
		1014948 ARF1_HUMAN (2-175): 2.57e-69: 209: 68.39		CYH2_HUMAN (639-933): 8.79e-99: 326: 34.00
+	Mm
		975367 ARF6_MOUSE (1-175): 2.77e-65: 199: 100.00		CYH1_MOUSE (638-933): 3.92e-99: 327: 35.22
+	Hs
		975195 ARF6_HUMAN (1-175): 2.77e-65: 199: 100.00		CYH2_HUMAN (639-933): 8.79e-99: 326: 34.00
+	Hs
		975048 ARF6_HUMAN (1-175): 2.77e-65: 199: 100.00		CYH1_HUMAN (638-933): 1.64e-98: 325: 35.76
+	Rn
		975369 ARF6_RAT (1-175): 2.77e-65: 199: 100.00		CYH2_RAT (639-933): 3.57e-98: 324: 33.67
+	Hs
		975090 ARF6_HUMAN (1-175): 2.77e-65: 199: 100.00		IQEC1_HUMAN (639-946): 4.49e-82: 294: 30.18
+	Dm
		54748 O18332_DROME (1-175): 8.52e-67: 204: 20.56		A1Z8W9_DROME (1325-1599): 2.61e-50: 199: 12.20
+	Dm
		54753 ARF1_DROME (2-175): 1.28e-64: 197: 70.12		A1Z8W9_DROME (1325-1599): 2.61e-50: 199: 12.20
+	Dm
		829711 ARF6_DROME (1-174): 4.01e-68: 206: 97.13		Q6U9V3_DROME (682-877): 1.52e-36: 153: 42.50
+	Sc
		536127 ARF1_YEAST (2-175): 9.86e-69: 208: 66.09		GEA2_YEAST (45-298): 1.78e-33: 143: 12.26
+	Sc
		535967 ARF1_YEAST (2-175): 9.86e-69: 208: 66.09		SEC7_YEAST (10-290): 2.59e-30: 133: 25.99
+	Sc
		536143 ARF1_YEAST (2-175): 9.86e-69: 208: 66.09		GEA1_YEAST (45-293): 1.93e-15: 85: 10.94
+	Hs
		975080 ARF6_HUMAN (1-175): 2.77e-65: 199: 100.00		BIG3_HUMAN (37-237): 6.95e-11: 70: 20.29