HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: Q8TD98 (Q8TD98)
MLL/AF4 fusion protein
Gene: Q8TD98

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	20153263
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 624
+	Hs
		850807 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		AFF1_HUMAN (36-624): 2.64e-47: 181: 76.40
+	Hs
		975285 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		KMT2C_HUMAN (5-617): 7.19e-28: 122: 11.36
+	Hs
		975340 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		AFF4_HUMAN (30-620): 1.37e-25: 114: 28.84
+	Hs
		975225 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Mm
		876677 KMT2A_MOUSE (1-3969): 0: 3189: 90.32		KMT2A_MOUSE (1-146): 1.71e-23: 108: 82.24
+	Hs
		975346 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		KMT2B_HUMAN (21-151): 6.29e-24: 109: 39.42
+	Hs
		975270 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		Q1WD23_HUMAN (40-97): 8.63e-17: 78.8: 98.28
+	Hs
		975294 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		TITIN_HUMAN (5-543): 4.7e-09: 62: 9.52
+	Hs
		152630 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		KMT2D_HUMAN (122-621): 7.88e-09: 61.2: 11.80
+	Hs
		1243852 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		KMT2C_HUMAN (5-617): 7.19e-28: 122: 11.36
+	Hs
		554310 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		MUC1_HUMAN (12-616): 2.7e-40: 160: 8.19
+	Hs
		152700 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		KMT2D_HUMAN (122-621): 7.88e-09: 61.2: 11.80
+	Hs
		1080127 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		KMT2C_HUMAN (5-617): 7.19e-28: 122: 11.36
+	Hs
		975264 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		KMT2A_HUMAN (6-146): 8.61e-25: 112: 90.48
+	Hs
		1056971 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		MDC1_HUMAN (5-621): 3.37e-32: 135: 10.71
+	Hs
		152654 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		KMT2D_HUMAN (122-621): 7.88e-09: 61.2: 11.80
+	Dm
		1129083 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		Q9VLS7_DROME (1-594): 7.98e-09: 61.2: 8.33
+	Hs
		203821 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		CABIN_HUMAN (7-456): 7.59e-10: 64.5: 12.50
+	Hs
		152701 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		KMT2D_HUMAN (122-621): 7.88e-09: 61.2: 11.80