HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: RYBP (Q8N488)
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
Gene: RYBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	26186194, 28514442, 27705803, 30217970, 10369680, 32296183, 33961781, 34133714, 34316702, 16943429, 22325352, 25416956, 16189514, 24981860, 35271311, unassigned1304, 17070805
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, tandem affinity purification, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, anti bait coimmunoprecipitation and 1 others more... two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 228
+	Mm
		193411 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		987989 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Mm
		1208123 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		1233162 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		1307837 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		YAF2_MOUSE (3-227): 5.87e-58: 183: 54.67
+	Hs
		1222214 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		718013 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		718000 BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		585013 RO52_HUMAN (33-392): 4.67e-43: 158: 13.14		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		718410 PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1233190 PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		620789 PCGF2_MOUSE (31-345): 1.16e-40: 149: 13.93		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Mm
		1208119 PCGF1_MOUSE (25-149): 1.99e-40: 146: 23.44		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		1233178 PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		1208122 PCGF6_MOUSE (31-157): 7.63e-39: 144: 23.08		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		718409 PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1222219 PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1222217 PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1108516 PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Dm
		1361718 RING1_DROME (1-159): 2.1e-47: 169: 74.84		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95