HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG15 (Q53QZ3)
Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)
Gene: ARHGAP15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	12650940
Identification Methods	pull down, filter binding, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007264 - small GTPase-mediated signal transduction GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 475
+	Hs
		988468 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG27_HUMAN (17-472): 8.75e-108: 341: 40.99
+	Hs
		988431 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG21_HUMAN (2-473): 6.12e-93: 310: 25.35
+	Hs
		586979 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		CHIN_HUMAN (179-470): 2.25e-76: 248: 23.61
+	Hs
		212765 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		SRGP3_HUMAN (103-475): 1.96e-71: 247: 17.53
+	Hs
		914009 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		CHIO_HUMAN (177-470): 1.75e-75: 246: 25.00
+	Mm
		988896 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		CHIO_MOUSE (205-470): 3.85e-77: 246: 27.60
+	Hs
		67650 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG32_HUMAN (246-472): 9.15e-69: 240: 29.06
+	Mm
		988897 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		RHG32_MOUSE (246-472): 1.53e-68: 240: 29.06
+	Hs
		988328 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG05_HUMAN (5-470): 1.46e-66: 234: 21.46
+	Hs
		988277 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG04_HUMAN (108-472): 9.2e-66: 229: 21.30
+	Hs
		156404 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG33_HUMAN (245-472): 6.39e-64: 226: 29.36
+	Hs
		988407 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG31_HUMAN (259-470): 4.71e-64: 226: 30.59
+	Hs
		269537 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		SRGP2_HUMAN (115-475): 9.18e-64: 225: 15.93
+	Hs
		539995 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		BCR_HUMAN (184-457): 9.89e-64: 225: 29.21
+	Mm
		988887 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		ABR_MOUSE (234-472): 1.2e-64: 225: 31.05
+	Hs
		260707 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		OPHN1_HUMAN (275-475): 8.84e-64: 222: 31.71
+	Hs
		65907 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG42_HUMAN (297-475): 1.04e-34: 140: 38.46
+	Mm
		988892 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		BCR_MOUSE (247-445): 2.38e-29: 124: 38.42
+	Hs
		988484 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG22_HUMAN (46-188): 2.28e-13: 74.5: 15.69
+	Mm
		988900 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		RHG22_MOUSE (37-188): 1.32e-12: 72.2: 16.25