HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	24457600, 36517590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0097421 - liver regeneration
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 746
+	Hs
		1028558 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1028670 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		516536 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		951979 SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1079987 SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		952203 SRSF3_MOUSE (15-99): 9.33e-28: 105: 43.53		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		1031345 PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		963528 TIAR_HUMAN (113-202): 2.85e-10: 61.5: 12.63		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331802 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		331803 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1029077 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		331795 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		516645 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		975239 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Sc
		376833 PABP_YEAST (123-203): 2.42e-12: 68.1: 22.73		SET2_YEAST (470-733): 1.22e-59: 216: 25.56
+	Hs
		975240 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		975231 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54