HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: HLX (Q14774)
H2.0-like homeobox protein (Homeobox protein HB24) (Homeobox protein HLX1)
Gene: HLX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Hs			1 488
+	Hs
		980933 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		HLX_HUMAN (1-488): 1.93e-62: 212: 100.00
+	Hs
		980605 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HLX_HUMAN (1-488): 1.93e-62: 212: 100.00
+	Hs
		764630 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		CUX1_HUMAN (55-432): 6.58e-33: 135: 17.13
+	Hs
		620144 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		PAX7_HUMAN (259-485): 1.84e-33: 134: 23.08
+	Hs
		620142 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		PAX7_HUMAN (259-485): 1.84e-33: 134: 23.08
+	Hs
		641379 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		PAX6_HUMAN (220-480): 5.58e-32: 128: 16.54
+	Hs
		641377 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		PAX6_HUMAN (220-480): 5.58e-32: 128: 16.54
+	Hs
		974243 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HHEX_HUMAN (136-396): 1.49e-32: 126: 30.42
+	Hs
		822627 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		LHX1_HUMAN (228-477): 9.85e-30: 122: 20.08
+	Hs
		882123 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		GSC_HUMAN (141-373): 7.08e-30: 119: 20.68
+	Hs
		679098 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLX1_HUMAN (229-346): 8.8e-29: 118: 32.80
+	Hs
		882121 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		GSC_HUMAN (141-373): 7.08e-30: 119: 20.68
+	Hs
		679096 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLX1_HUMAN (229-346): 8.8e-29: 118: 32.80
+	Hs
		211840 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLX3_HUMAN (230-347): 3.36e-26: 109: 34.75
+	Hs
		213323 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		TLX2_HUMAN (270-347): 7.82e-26: 108: 41.03
+	Hs
		211837 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLX3_HUMAN (230-347): 3.36e-26: 109: 34.75
+	Hs
		213321 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		TLX2_HUMAN (270-347): 7.82e-26: 108: 41.03
+	Hs
		980663 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HESX1_HUMAN (157-349): 2.74e-26: 107: 18.65
+	Hs
		211839 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		TLX3_HUMAN (230-347): 3.36e-26: 109: 34.75
+	Hs
		213322 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		TLX2_HUMAN (270-347): 7.82e-26: 108: 41.03