HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	28514442, 33961781, 37071682, 35575683
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Actin
Common GO terms	GO:0005524 - ATP binding GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton GO:0019901 - protein kinase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 376
+	Hs
		1200979 ACTBL_HUMAN (4-377): 0: 712: 87.97		POTEE_HUMAN (3-376): 0: 693: 85.03
+	Hs
		952875 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		993208 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		993424 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTH_HUMAN (1-376): 0: 589: 87.77
+	Hs
		995631 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		996469 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Dm
		387021 ACT4_DROME (1-377): 0: 647: 92.04		ACT5_DROME (1-376): 0: 597: 89.10
+	Dm
		387022 ACT4_DROME (1-377): 0: 647: 92.04		ACT1_DROME (1-376): 0: 597: 90.69
+	Dm
		386963 ACT4_DROME (1-377): 0: 647: 92.04		ACT2_DROME (1-376): 0: 595: 90.16
+	Dm
		387037 ACT4_DROME (1-377): 0: 647: 92.04		ACT3_DROME (1-376): 0: 594: 88.83
+	Dm
		387039 ACT4_DROME (1-377): 0: 647: 92.04		ACT6_DROME (1-376): 0: 594: 88.83
+	Sp
		534526 ACT_SCHPO (4-377): 0: 644: 89.04		ACT_SCHPO (3-376): 0: 586: 85.29
+	Sc
		948620 ACT_YEAST (4-377): 0: 643: 86.63		ACT_YEAST (1-376): 0: 583: 82.98
+	At
		920945 ACT11_ARATH (1-377): 0: 620: 87.80		ACT7_ARATH (2-376): 0: 582: 83.73
+	Ce
		534393 ACT2_CAEEL (1-377): 0: 596: 94.43		ACT2_CAEEL (1-376): 0: 599: 90.16
+	Ce
		534394 ACT2_CAEEL (1-377): 0: 596: 94.43		ACT4_CAEEL (1-376): 0: 599: 90.16
+	Ce
		515951 ACT2_CAEEL (1-377): 0: 596: 94.43		ACT3_CAEEL (1-376): 0: 598: 90.16
+	Ce
		515952 ACT4_CAEEL (1-377): 0: 596: 93.90		ACT3_CAEEL (1-376): 0: 598: 90.16
+	Zm
		83824 B6TQ08_MAIZE (1-377): 0: 597: 88.33		B6TQ08_MAIZE (2-376): 0: 584: 84.00