HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Hs			1 282
+	Hs
		963969 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1029063 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		963970 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1028792 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		SRSF8_HUMAN (1-282): 5.34e-41: 144: 100.00
+	Hs
		963976 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	At
		1163070 SR30_ARATH (4-253): 1.45e-54: 185: 36.33		CYP59_ARATH (2-263): 2.25e-33: 129: 16.98
+	Hs
		1029160 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		1028634 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		993869 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		1028873 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Hs
		992743 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516478 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Sc
		376750 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		PABP_YEAST (2-103): 2.06e-20: 92.5: 19.61
+	Hs
		1020247 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Mm
		857340 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Mm
		857324 Q542V3_MOUSE (1-468): 2.02e-54: 191: 80.38		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Mm
		936481 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIAR_MOUSE (12-152): 9.18e-17: 81.4: 12.68
+	Hs
		516493 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	At
		1093121 SR30_ARATH (4-253): 1.45e-54: 185: 36.33		SRC28_ARATH (9-182): 2.52e-17: 80.7: 30.86
+	Cn
		111495 J9VJ75_CRYNH (3-179): 9.05e-43: 161: 30.85		J9VUR9_CRYNH (13-103): 4.39e-15: 77.1: 17.58