HitPredict

Interactor 1: SET1A (E9PYH6)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (SET domain-containing protein 1A)
Gene: Setd1a

Interactor 2: H33 (P84244)
Histone H3.3
Gene: H3-3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24368734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1716 Mm			1 136
+	Hs
		175872 SET1A_HUMAN (1-1716): 5.72e-178: 584: 87.53		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		175899 SET1A_HUMAN (1-1716): 5.72e-178: 584: 87.53		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		998234 KMT2A_HUMAN (1257-1716): 1.28e-76: 285: 26.21		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1016789 KMT2A_HUMAN (1257-1716): 1.28e-76: 285: 26.21		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		1041540 KMT2A_HUMAN (1257-1716): 1.28e-76: 285: 26.21		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Hs
		1041551 KMT2A_HUMAN (1257-1716): 1.28e-76: 285: 26.21		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		998821 EHMT1_HUMAN (623-1714): 6.92e-75: 276: 13.53		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1017218 EHMT1_HUMAN (623-1714): 6.92e-75: 276: 13.53		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		1162047 EHMT1_HUMAN (623-1714): 6.92e-75: 276: 13.53		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Sp
		489146 SET1_SCHPO (1182-1716): 2.65e-74: 270: 28.31		H31_SCHPO (1-136): 1.12e-57: 177: 91.91
+	Dm
		381695 EZ_DROME (1141-1696): 4.21e-74: 266: 14.06		H3_DROME (1-136): 5.34e-59: 180: 97.06
+	Mm
		1017354 EZH2_MOUSE (1218-1699): 2.33e-73: 263: 17.30		H33_MOUSE (1-136): 1.13e-59: 182: 100.00
+	Mm
		1017361 Q6AXH7_MOUSE (1218-1699): 2.62e-73: 263: 17.14		H33_MOUSE (1-136): 1.13e-59: 182: 100.00
+	Hs
		998359 EZH2_HUMAN (1202-1699): 1.3e-72: 261: 16.79		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1016892 EZH2_HUMAN (1202-1699): 1.3e-72: 261: 16.79		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		1155419 EZH2_HUMAN (1202-1699): 1.3e-72: 261: 16.79		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Hs
		1155464 EZH2_HUMAN (1202-1699): 1.3e-72: 261: 16.79		H3C_HUMAN (1-136): 2e-56: 173: 95.59
+	Hs
		883513 KMT2A_HUMAN (1257-1716): 1.28e-76: 285: 26.21		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76
+	Sc
		805564 SET1_YEAST (1288-1716): 1.78e-69: 258: 26.71		H3_YEAST (1-136): 3.63e-54: 168: 90.44
+	Hs
		883692 EHMT1_HUMAN (623-1714): 6.92e-75: 276: 13.53		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76