Protein: H2A2B
Histone H2A type 2-B (H2A-clustered histone 21)

Gene: H2A2B, H2AC21
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q8IUE6

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0005634 - nucleus
GO:0030527 - structural constituent of chromatin
GO:0031492 - nucleosomal DNA binding
GO:0046982 - protein heterodimerization activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

917544

H4
Histone H4

4

12

High-throughput

0.881

High

876839

NP1L1
Nucleosome assembly protein 1-like 1

3

14

High-throughput

0.861

High

1216241

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.861

High

1174590

H32
Histone H3.2

3

20

High-throughput

0.827

High

555534

H2AX
Histone H2AX

2

16

High-throughput

0.811

High

996754

SSRP1
FACT complex subunit SSRP1

2

20

High-throughput

0.811

High

1216276

H2AW
Core histone macro-H2A.2

2

17

High-throughput

0.811

High

391776

H2A1B
Histone H2A type 1-B/E

2

15

High-throughput

0.789

High

934946

H31
Histone H3.1

2

20

High-throughput

0.789

High

998866

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.778

High

918497

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

971251

H11
Histone H1.1

4

20

High-throughput

0.697

High

203730

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

4

High-throughput

0.691

High

470079

H2AZ
Histone H2A.Z

1

19

High-throughput

0.691

High

470440

H2A1
Histone H2A type 1

1

15

High-throughput

0.691

High

952450

H33
Histone H3.3

1

20

High-throughput

0.691

High

1087239

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1151350

H2A2A
Histone H2A type 2-A

1

14

High-throughput

0.691

High

1187486

H2BWT
Histone H2B type W-T

1

20

High-throughput

0.691

High

1216224

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.691

High

564959

HMGA1
High mobility group protein HMG-I/HMG-Y

3

6

High-throughput

0.671

High

1216220

ZC3H3
Zinc finger CCCH domain-containing protein 3

3

4

High-throughput

0.667

High

1086203

H31T
Histone H3.1t

1

20

High-throughput

0.665

High

1216239

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

1216227

SIR6
NAD-dependent protein deacylase sirtuin-6

3

9

High-throughput

0.656

High

907388

RS8
Small ribosomal subunit protein eS8

3

0

High-throughput

0.638

High

176229

PPM1G
Protein phosphatase 1G

2

11

High-throughput

0.635

High

426686

H10
Histone H1.0

2

5

High-throughput

0.621

High

559162

H15
Histone H1.5

2

20

High-throughput

0.621

High

559808

H12
Histone H1.2

2

20

High-throughput

0.621

High

229433

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

Small-scale

0.618

High

707681

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

832567

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

886151

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.618

High

1059717

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

1216249

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.618

High

130258

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

2

9

High-throughput

0.611

High

417830

DPOLB
DNA polymerase beta

2

1

High-throughput

0.611

High

455622

PARP1
Poly [ADP-ribose] polymerase 1

2

20

High-throughput

0.611

High

1216219

APLF
Aprataxin and PNK-like factor

2

4

High-throughput

0.611

High

1216229

ZBT38
Zinc finger and BTB domain-containing protein 38

2

1

High-throughput

0.611

High

1216278

PEF1
Peflin

2

2

High-throughput

0.611

High

395105

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

1216237

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

1119553

MIDN
Midnolin

1

0

High-throughput

0.586

High

211758

BUD23
Probable 18S rRNA

2

0

High-throughput

0.585

High

1216265

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

2

0

High-throughput

0.585

High

553115

RFA2
Replication protein A 32 kDa subunit

2

3

High-throughput

0.584

High

1067038

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

1116374

LARP7
La-related protein 7

2

20

High-throughput

0.584

High

180365

MAGB2
Melanoma-associated antigen B2

1

6

High-throughput

0.536

High

273452

PPM1B
Protein phosphatase 1B

1

2

High-throughput

0.536

High

316082

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.536

High

400978

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.536

High

449762

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

489137

H14
Histone H1.4

1

20

High-throughput

0.536

High

508606

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.536

High

509051

TOP2A
DNA topoisomerase 2-alpha

1

6

High-throughput

0.536

High

550848

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.536

High

578013

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.536

High

608582

H1T
Histone H1t

1

20

High-throughput

0.536

High

642435

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

686001

ARRB2
Beta-arrestin-2

1

4

High-throughput

0.536

High

736568

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

759723

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.536

High

773437

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

827241

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.536

High

842560

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.536

High

900198

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

913618

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

916259

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.536

High

916679

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.536

High

921895

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

922249

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

942774

SRPK2
SRSF protein kinase 2

1

9

High-throughput

0.536

High

967049

XPC
DNA repair protein complementing XP-C cells

1

5

High-throughput

0.536

High

992835

SRSF1
Serine/arginine-rich splicing factor 1

1

12

High-throughput

0.536

High

993761

SRSF4
Serine/arginine-rich splicing factor 4

1

14

High-throughput

0.536

High

1061161

NUMA1
Nuclear mitotic apparatus protein 1

1

11

High-throughput

0.536

High

1158900

MED27
Mediator of RNA polymerase II transcription subunit 27

1

2

High-throughput

0.536

High

1176025

H1FNT
Testis-specific H1 histone

1

1

High-throughput

0.536

High

1190967

GOGA7
Golgin subfamily A member 7

1

1

High-throughput

0.536

High

1200472

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.536

High

1216228

ZN491
Zinc finger protein 491

1

1

High-throughput

0.536

High

1216230

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.536

High

1216231

FLCN
Folliculin

1

1

High-throughput

0.536

High

1216233

ZN398
Zinc finger protein 398

1

2

High-throughput

0.536

High

1216234

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

2

High-throughput

0.536

High

1216246

ZN668
Zinc finger protein 668

1

2

High-throughput

0.536

High

1216247

ZN512
Zinc finger protein 512

1

2

High-throughput

0.536

High

1216255

MBB1A
Myb-binding protein 1A

1

2

High-throughput

0.536

High

1216257

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

6

High-throughput

0.536

High

1216259

RBM4
RNA-binding protein 4

1

10

High-throughput

0.536

High

1216264

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1216271

PRDM5
PR domain zinc finger protein 5

1

1

High-throughput

0.536

High

1216274

LYAR
Cell growth-regulating nucleolar protein

1

2

High-throughput

0.536

High

1216277

SPAST
Spastin

1

3

High-throughput

0.536

High

1216279

CFDP1
Craniofacial development protein 1

1

4

High-throughput

0.536

High

1216281

PURG
Purine-rich element-binding protein gamma

1

4

High-throughput

0.536

High

1216282

ZN346
Zinc finger protein 346

1

5

High-throughput

0.536

High

1216283

RUVB2
RuvB-like 2

1

7

High-throughput

0.536

High

1216285

YBOX2
Y-box-binding protein 2

1

19

High-throughput

0.536

High

313849

SVIL
Supervillin

1

1

High-throughput

0.515

High

417343

ENOA
Alpha-enolase

1

1

High-throughput

0.515

High

595940

HNF1A
Hepatocyte nuclear factor 1-alpha

1

1

Small-scale

0.515

High

1216238

H1X
Histone H1.10

1

4

High-throughput

0.515

High

1216244

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

9

Small-scale

0.515

High

328891

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

911180

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

923099

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

1216254

MEP50
Methylosome protein WDR77

1

7

Small-scale

0.501

High

302347

CMTA2
Calmodulin-binding transcription activator 2

1

0

High-throughput

0.493

High

920495

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.493

High

271355

NPM3
Nucleoplasmin-3

1

7

High-throughput

0.489

High

273153

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.489

High

686699

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.489

High

713114

SDC2
Syndecan-2

1

1

High-throughput

0.489

High

789480

RBM34
RNA-binding protein 34

1

10

High-throughput

0.489

High

790456

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.489

High

807429

RS10
Small ribosomal subunit protein eS10

1

4

High-throughput

0.489

High

851576

NEK4
Serine/threonine-protein kinase Nek4

1

15

High-throughput

0.489

High

923419

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.489

High

951635

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.489

High

1028721

SRSF5
Serine/arginine-rich splicing factor 5

1

13

High-throughput

0.489

High

1040605

KRR1
KRR1 small subunit processome component homolog

1

5

High-throughput

0.489

High

1051785

LY6D
Lymphocyte antigen 6D

1

1

High-throughput

0.489

High

1054844

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1072775

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.489

High

1077015

MARE1
Microtubule-associated protein RP/EB family member 1

1

2

High-throughput

0.489

High

1170406

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.489

High

1201524

ZCH18
Zinc finger CCCH domain-containing protein 18

1

12

High-throughput

0.489

High

1216222

CA174
UPF0688 protein C1orf174

1

2

High-throughput

0.489

High

1216232

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

9

High-throughput

0.489

High

1216236

SSH1
Protein phosphatase Slingshot homolog 1

1

1

High-throughput

0.489

High

1216248

TECTB
Beta-tectorin

1

1

High-throughput

0.489

High

1216256

UTP23
rRNA-processing protein UTP23 homolog

1

1

High-throughput

0.489

High

1216258

ELOV1
Very long chain fatty acid elongase 1

1

1

High-throughput

0.489

High

1216261

MAK16
Protein MAK16 homolog

1

1

High-throughput

0.489

High

1216263

RM18
Large ribosomal subunit protein uL18m

1

1

High-throughput

0.489

High

1216275

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.489

High

1216284

KLH20
Kelch-like protein 20

1

1

High-throughput

0.489

High

210112

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

233532

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

244634

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

303345

HEXI1
Protein HEXIM1

1

12

High-throughput

0.479

High

308856

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.479

High

347244

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

360118

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

Small-scale

0.479

High

379580

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

396956

HMGN1
Non-histone chromosomal protein HMG-14

1

4

High-throughput

0.479

High

472884

H2AB2
Histone H2A-Bbd type 2/3

1

17

High-throughput

0.479

High

487991

RARA
Retinoic acid receptor alpha

1

8

Small-scale

0.479

High

532572

TCTP
Translationally-controlled tumor protein

1

3

High-throughput

0.479

High

569858

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

591007

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

631492

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

651615

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

708697

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

760158

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.479

High

908776

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

921332

RBX1
E3 ubiquitin-protein ligase RBX1

1

4

High-throughput

0.479

High

969831

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

1035869

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1048135

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

Small-scale

0.479

High

1063481

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1066352

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1152497

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

1

5

High-throughput

0.479

High

1184200

MEPCE
7SK snRNA methylphosphate capping enzyme

1

12

High-throughput

0.479

High

1193117

SLN11
Schlafen family member 11

1

6

Small-scale

0.479

High

1216218

ARMC8
Armadillo repeat-containing protein 8

1

2

High-throughput

0.479

High

1216243

ZN707
Zinc finger protein 707

1

2

High-throughput

0.479

High

1216245

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

1216260

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

1216266

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

1216267

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1216280

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1216286

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

654009

MAP4
Microtubule-associated protein 4

1

14

High-throughput

0.470

High

1065824

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

High-throughput

0.470

High

1216250

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1216272

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.458

High

1216273

RN146
E3 ubiquitin-protein ligase RNF146

1

0

High-throughput

0.458

High

47435

RPSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.445

High

70167

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

5

High-throughput

0.445

High

92259

E9PAV9
G patch domain-containing protein 4

1

3

High-throughput

0.437

High

149019

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.437

High

255904

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

720856

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

824166

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

1061487

CUL7
Cullin-7

1

1

High-throughput

0.437

High

1136155

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

1140589

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.437

High

1146587

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

1216221

TM192
Transmembrane protein 192

1

1

High-throughput

0.437

High

1216235

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

3

High-throughput

0.437

High

1216252

SPI2B
Spindlin-2B

1

1

High-throughput

0.437

High

1216253

RBM4B
RNA-binding protein 4B

1

10

High-throughput

0.437

High

1216262

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

7

High-throughput

0.437

High

1216268

RC3H2
Roquin-2

1

12

High-throughput

0.437

High

1216269

NGB
Neuroglobin

1

1

High-throughput

0.437

High

1216270

ANLN
Anillin

1

3

High-throughput

0.437

High

1133004

GPTC4
G patch domain-containing protein 4

1

3

High-throughput

0.407

High

615430

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

1087771

RTN1
Reticulon-1

1

0

High-throughput

0.279

Low

1216226

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1216240

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.279

Low

1216242

ZN428
Zinc finger protein 428

1

0

High-throughput

0.279

Low

1216251

F118B
Protein FAM118B

1

0

High-throughput

0.279

Low

1149548

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.269

Low

1216223

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.269

Low

1216225

STX19
Syntaxin-19

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024