Protein: IRF3
Interferon regulatory factor 3 (IRF-3)

Gene: IRF3
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q14653

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 - DNA-binding transcription activator activity
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1056413

IRF3
Interferon regulatory factor 3

52

17

Small-scale

0.996

High

1056440

CBP
CREB-binding protein

28

17

Small-scale

0.993

High

998708

EP300
Histone acetyltransferase p300

11

18

Small-scale

0.978

High

1056444

IRF7
Interferon regulatory factor 7

5

17

Small-scale

0.924

High

1056470

TBK1
Serine/threonine-protein kinase TBK1

33

14

Small-scale

0.770

High

1039452

IRF5
Interferon regulatory factor 5

2

16

Small-scale

0.768

High

352883

IFNB
Interferon beta

13

20

Small-scale

0.756

High

1050193

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

10

14

Small-scale

0.754

High

397967

ISG15
Ubiquitin-like protein ISG15

10

10

Small-scale

0.748

High

1056431

MAVS
Mitochondrial antiviral-signaling protein

6

5

Small-scale

0.739

High

1056432

STING
Stimulator of interferon genes protein

7

2

Small-scale

0.739

High

352755

IFNA1
Interferon alpha-1/13

5

20

Small-scale

0.709

High

431856

HS90A
Heat shock protein HSP 90-alpha

3

7

Small-scale

0.685

High

584964

RO52
E3 ubiquitin-protein ligase TRIM21

3

8

Small-scale

0.678

High

1056434

TCAM1
TIR domain-containing adapter molecule 1

4

2

Small-scale

0.676

High

321899

RIGI
Antiviral innate immune response receptor RIG-I

3

7

Small-scale

0.650

High

501050

IRF1
Interferon regulatory factor 1

1

16

Small-scale

0.646

High

456281

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

3

7

Small-scale

0.640

High

528263

CCL5
C-C motif chemokine 5

3

10

Small-scale

0.640

High

1025383

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

4

Small-scale

0.640

High

1036575

SQSTM
Sequestosome-1

3

3

Small-scale

0.640

High

1056441

TANK
TRAF family member-associated NF-kappa-B activator

3

2

Small-scale

0.640

High

301397

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

2

2

High-throughput

0.628

High

1056445

GLMN
Glomulin

2

0

High-throughput

0.602

High

1056451

MOCOS
Molybdenum cofactor sulfurase

2

0

High-throughput

0.602

High

1056472

MSRA
Mitochondrial peptide methionine sulfoxide reductase

2

0

High-throughput

0.602

High

800778

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.598

High

414287

RB
Retinoblastoma-associated protein

1

2

High-throughput

0.586

High

660140

RBL1
Retinoblastoma-like protein 1

1

2

High-throughput

0.586

High

1037933

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

Small-scale

0.585

High

162742

XPO1
Exportin-1

2

3

Small-scale

0.584

High

181861

SOCS1
Suppressor of cytokine signaling 1

2

8

Small-scale

0.584

High

227457

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

352770

IFNA2
Interferon alpha-2

2

20

Small-scale

0.584

High

352844

IFN14
Interferon alpha-14

2

20

Small-scale

0.584

High

667336

IL12A
Interleukin-12 subunit alpha

2

7

Small-scale

0.584

High

1016175

FOXO1
Forkhead box protein O1

2

6

Small-scale

0.584

High

1024676

TRAF3
TNF receptor-associated factor 3

2

19

Small-scale

0.584

High

1045324

APR
Phorbol-12-myristate-13-acetate-induced protein 1

2

1

Small-scale

0.584

High

1019304

TRI26
Tripartite motif-containing protein 26

1

10

Small-scale

0.578

High

1056471

HERC5
E3 ISG15--protein ligase HERC5

1

5

Small-scale

0.578

High

213546

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

High-throughput

0.573

High

930844

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

0

Small-scale

0.569

High

130889

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

Small-scale

0.561

High

297058

TOM70
Mitochondrial import receptor subunit TOM70

1

2

Small-scale

0.561

High

800887

MK09
Mitogen-activated protein kinase 9

1

1

Small-scale

0.561

High

1056426

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

Small-scale

0.561

High

856019

ZN143
Zinc finger protein 143

2

0

Small-scale

0.559

High

967172

EWS
RNA-binding protein EWS

1

2

High-throughput

0.541

High

311543

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.536

High

313132

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

2

High-throughput

0.536

High

499268

KIT
Mast/stem cell growth factor receptor Kit

1

1

High-throughput

0.536

High

656225

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.536

High

674428

UFO
Tyrosine-protein kinase receptor UFO

1

2

High-throughput

0.536

High

825951

FAS
Fatty acid synthase

1

1

High-throughput

0.536

High

856208

HXK2
Hexokinase-2

1

3

High-throughput

0.536

High

997120

RBL2
Retinoblastoma-like protein 2

1

2

High-throughput

0.536

High

1051276

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.536

High

1056414

SMC1A
Structural maintenance of chromosomes protein 1A

1

3

High-throughput

0.536

High

1056418

GRDN
Girdin

1

3

High-throughput

0.536

High

1056454

WRIP1
ATPase WRNIP1

1

1

High-throughput

0.536

High

1056476

SALL2
Sal-like protein 2

1

1

High-throughput

0.536

High

1056480

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.536

High

238677

IMA7
Importin subunit alpha-7

1

5

Small-scale

0.534

High

1056437

PIAS4
E3 SUMO-protein ligase PIAS4

1

3

Small-scale

0.534

High

1056479

MAFB
Transcription factor MafB

1

3

Small-scale

0.534

High

486202

IL8
Interleukin-8

2

10

Small-scale

0.533

High

1056422

OTUD1
OTU domain-containing protein 1

2

2

Small-scale

0.533

High

992000

BAX
Apoptosis regulator BAX

1

1

Small-scale

0.527

High

777184

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

681848

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.515

High

853282

IMA1
Importin subunit alpha-1

1

5

Small-scale

0.515

High

1035433

SMAD4
Mothers against decapentaplegic homolog 4

1

4

Small-scale

0.515

High

1056416

SMAD2
Mothers against decapentaplegic homolog 2

1

4

Small-scale

0.515

High

48353

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.513

High

152964

RIOK3
Serine/threonine-protein kinase RIO3

1

0

Small-scale

0.513

High

318316

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.513

High

1017075

TROP
Trophinin

1

0

High-throughput

0.513

High

1056417

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

1056456

SORT
Sortilin

1

0

High-throughput

0.513

High

1056466

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.513

High

1056469

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.513

High

1056478

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

1056475

GRIP1
Glutamate receptor-interacting protein 1

1

2

Small-scale

0.506

High

174889

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

279554

FLOT1
Flotillin-1

1

6

High-throughput

0.500

High

1052392

FLOT2
Flotillin-2

1

6

High-throughput

0.500

High

1056455

PSB7
Proteasome subunit beta type-7

1

9

High-throughput

0.500

High

315829

AGRL2
Adhesion G protein-coupled receptor L2

1

1

High-throughput

0.489

High

1056415

SLMAP
Sarcolemmal membrane-associated protein

1

2

High-throughput

0.489

High

1056447

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.489

High

989295

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.481

High

1056446

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

1056463

TRI55
Tripartite motif-containing protein 55

1

16

High-throughput

0.481

High

1056435

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.480

High

1056474

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

175681

TRI18
E3 ubiquitin-protein ligase Midline-1

1

14

Small-scale

0.479

High

177296

HDAC3
Histone deacetylase 3

1

5

Small-scale

0.479

High

212255

CIKS
E3 ubiquitin ligase TRAF3IP2

1

1

Small-scale

0.479

High

237495

TLR2
Toll-like receptor 2

1

13

Small-scale

0.479

High

262272

ULK1
Serine/threonine-protein kinase ULK1

1

2

Small-scale

0.479

High

263436

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

3

Small-scale

0.479

High

352614

TNFA
Tumor necrosis factor

1

7

Small-scale

0.479

High

352788

IFNA7
Interferon alpha-7

1

20

Small-scale

0.479

High

364114

CXL10
C-X-C motif chemokine 10

1

10

Small-scale

0.479

High

438174

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

456230

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

1

7

Small-scale

0.479

High

475026

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

10

Small-scale

0.479

High

540846

PO2F1
POU domain, class 2, transcription factor 1

1

4

Small-scale

0.479

High

594249

MX1
Interferon-induced GTP-binding protein Mx1

1

1

Small-scale

0.479

High

607071

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

610404

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

614323

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

Small-scale

0.479

High

668684

PML
Protein PML

1

13

Small-scale

0.479

High

728917

AHR
Aryl hydrocarbon receptor

1

1

Small-scale

0.479

High

808608

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.479

High

841072

TNF10
Tumor necrosis factor ligand superfamily member 10

1

7

Small-scale

0.479

High

886001

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

Small-scale

0.479

High

908540

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

957704

XIAP
E3 ubiquitin-protein ligase XIAP

1

3

Small-scale

0.479

High

959929

TF2B
Transcription initiation factor IIB

1

2

Small-scale

0.479

High

983125

UBE3A
Ubiquitin-protein ligase E3A

1

6

Small-scale

0.479

High

1020661

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1040983

CUL1
Cullin-1

1

1

Small-scale

0.479

High

1052972

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

Small-scale

0.479

High

1056419

TBB8
Tubulin beta-8 chain

1

2

High-throughput

0.479

High

1056421

ZC12A
Endoribonuclease ZC3H12A

1

2

Small-scale

0.479

High

1056425

OTU7B
OTU domain-containing protein 7B

1

3

Small-scale

0.479

High

1056428

WDR82
WD repeat-containing protein 82

1

1

Small-scale

0.479

High

1056429

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1056430

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

1056433

IFNL1
Interferon lambda-1

1

7

Small-scale

0.479

High

1056436

IFNL3
Interferon lambda-3

1

7

Small-scale

0.479

High

1056438

IL27A
Interleukin-27 subunit alpha

1

3

Small-scale

0.479

High

1056439

HDAC2
Histone deacetylase 2

1

5

Small-scale

0.479

High

1056443

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

Small-scale

0.479

High

1056450

FBX17
F-box only protein 17

1

1

Small-scale

0.479

High

1056457

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

2

Small-scale

0.479

High

1056458

CCL19
C-C motif chemokine 19

1

10

Small-scale

0.479

High

1056459

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.479

High

1056460

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

1056461

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

Small-scale

0.479

High

1056462

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

Small-scale

0.479

High

1056464

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

10

Small-scale

0.479

High

1056467

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

Small-scale

0.479

High

1056468

FBX6
F-box only protein 6

1

1

Small-scale

0.479

High

1056477

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

298516

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

127268

IPO5
Importin-5

1

0

Small-scale

0.458

High

134041

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

314327

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.458

High

821112

GSHB
Glutathione synthetase

1

0

Small-scale

0.458

High

1056020

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.458

High

1056420

Q53FC7
Heat shock 70kDa protein 6

1

0

High-throughput

0.458

High

1056427

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

Small-scale

0.458

High

1056449

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1056465

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

Small-scale

0.458

High

1056448

Q96BE0
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.437

High

1056424

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.328

High

1056452

CE034
Uncharacterized protein C5orf34

2

0

High-throughput

0.328

High

213268

SNG3
Synaptogyrin-3

1

0

High-throughput

0.279

Low

530886

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.279

Low

1056453

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

834971

PSN2
Presenilin-2

1

0

High-throughput

0.269

Low

1056423

TEX36
Testis-expressed protein 36

1

0

High-throughput

0.249

Low

1056442

MRP2
ATP-binding cassette sub-family C member 2

1

0

Small-scale

0.249

Low

1056473

TMED7
Transmembrane emp24 domain-containing protein 7

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024