Protein: ICOS
Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD antigen CD278)

Gene: ICOS
Organism: Homo sapiens
Interactions: 23
UniProt ID: Q9Y6W8

Gene Ontology (top 5):
GO:0002517 - T cell tolerance induction
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0031295 - T cell costimulation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

271606

ICOSL
ICOS ligand

3

1

Small-scale

0.880

High

1491864

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.631

High

699914

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

1

Small-scale

0.611

High

378217

TNFA
Tumor necrosis factor

2

0

High-throughput

0.585

High

1459856

TBK1
Serine/threonine-protein kinase TBK1

1

1

Small-scale

0.536

High

1491756

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.518

High

472216

TRFM
Melanotransferrin

1

0

High-throughput

0.513

High

834704

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

1062203

PCDH1
Protocadherin-1

1

0

High-throughput

0.513

High

1461238

TRHDE
Thyrotropin-releasing hormone-degrading ectoenzyme

1

0

High-throughput

0.513

High

288055

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

Small-scale

0.426

High

321389

ERLN2
Erlin-2

1

0

Small-scale

0.426

High

1094320

LCP2
Lymphocyte cytosolic protein 2

1

0

Small-scale

0.426

High

1041472

ACY1
Aminoacylase-1

2

0

High-throughput

0.318

High

1294650

CD20B
Cell division cycle protein 20 homolog B

1

0

High-throughput

0.279

Low

1430714

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

365504

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.249

Low

171796

GAK
Cyclin-G-associated kinase

1

0

Small-scale

0.232

Low

224872

MAAI
Maleylacetoacetate isomerase

1

0

Small-scale

0.232

Low

833708

NAA10
N-alpha-acetyltransferase 10

1

0

Small-scale

0.232

Low

857012

BAG6
Large proline-rich protein BAG6

1

0

Small-scale

0.232

Low

1060597

KLC1
Kinesin light chain 1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025