Protein: SARM1
NAD(+) hydrolase sarm1 (NADase sarm1) (EC 3.2.2.6) (Sterile alpha and TIR motif-containing protein 1) (Tir-1 homolog)

Gene: SARM1, Sarm
Organism: Drosophila melanogaster
Interactions: 101
UniProt ID: Q6IDD9

Gene Ontology (top 5):
GO:0003953 - NAD+ nucleosidase activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0019677 - NAD+ catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1234089

Q7K105
LD20892p

1

2

Small-scale

0.618

High

1234090

Q7KHK9
DREAM

2

2

High-throughput

0.521

High

1234128

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.486

High

120307

M9PD17
Gigas, isoform B

1

3

High-throughput

0.479

High

1234102

FOXO
Forkhead box protein O

1

8

High-throughput

0.479

High

1234124

WEK
Zinc finger protein weckle

1

6

Small-scale

0.479

High

1234154

4EBP
Eukaryotic translation initiation factor 4E-binding protein

1

0

High-throughput

0.458

High

55431

A1Z9E3
Elongation factor Tu

1

3

High-throughput

0.445

High

55770

A1Z9K0
Uncharacterized protein, isoform B

1

2

High-throughput

0.445

High

58082

A1ZBE9
Methionine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.445

High

356763

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

13

High-throughput

0.445

High

782713

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

3

High-throughput

0.445

High

823760

SQH
Myosin regulatory light chain sqh

1

1

High-throughput

0.445

High

834843

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.445

High

909861

PFKA
ATP-dependent 6-phosphofructokinase

1

1

High-throughput

0.445

High

911729

POLO
Serine/threonine-protein kinase polo

1

6

High-throughput

0.445

High

929301

KC1A
Casein kinase I isoform alpha

1

7

High-throughput

0.445

High

1234098

ENA
Protein enabled

1

10

High-throughput

0.445

High

1234099

Q8T4G5
AFG3 like matrix AAA peptidase subunit 2, isoform A

1

2

High-throughput

0.445

High

1234101

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.445

High

1234104

Q9V3V6
26S proteasome regulatory complex subunit p50

1

11

High-throughput

0.445

High

1234105

Q9V405
26S proteasome regulatory subunit 6B

1

4

High-throughput

0.445

High

1234110

Q9V9Q4
LD43819p

1

1

High-throughput

0.445

High

1234113

Q9VAX8
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.445

High

1234119

IPO9
Importin-9

1

13

High-throughput

0.445

High

1234123

Q9VJH2
Aspartyl-tRNA synthetase, mitochondrial, isoform A

1

4

High-throughput

0.445

High

1234129

Q9VQI5
Interferon-related developmental regulator 1

1

1

High-throughput

0.445

High

1234132

FRL
Formin-like protein

1

2

High-throughput

0.445

High

1234133

AIMP2
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.445

High

1234134

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.445

High

1234135

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

High-throughput

0.445

High

1234138

SYRC
Probable arginine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

1234151

Q9W4C4
GM14014p

1

1

High-throughput

0.445

High

1234155

SYQ
Probable glutamine--tRNA ligase

1

1

High-throughput

0.445

High

1234092

Q7KS72
C15

1

2

High-throughput

0.439

High

68717

A8JQV1
Uncharacterized protein, isoform C

1

2

High-throughput

0.437

High

68931

MBD56
Methyl-CpG-binding domain protein 5/6 homolog sba

1

1

High-throughput

0.437

High

1234100

Q8T9L5
Serine/threonine-protein kinase STK11

1

9

High-throughput

0.437

High

1234152

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.437

High

1234118

Q9VEP0
Regulatory protein zeste

1

0

High-throughput

0.426

High

1234125

NFS1
Cysteine desulfurase, mitochondrial

1

0

High-throughput

0.426

High

1234147

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

1234115

Q9VD99
Homeodomain-containing protein

1

1

High-throughput

0.417

High

53122

A1Z7K8
AaRS-interacting multifunctional protein 1

1

1

High-throughput

0.407

High

54608

A1Z8U0
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.407

High

263374

PENG
Protein penguin

1

2

High-throughput

0.407

High

264398

O62530
Adaptor protein complex 2, mu subunit, isoform A

1

1

High-throughput

0.407

High

305038

C3G
Guanine nucleotide-releasing factor 2

1

6

High-throughput

0.407

High

561574

SPTCA
Spectrin alpha chain

1

9

High-throughput

0.407

High

654850

MA205
205 kDa microtubule-associated protein

1

2

High-throughput

0.407

High

704351

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.407

High

773366

RFC1
Replication factor C subunit 1

1

7

High-throughput

0.407

High

852181

COPB
Coatomer subunit beta

1

3

High-throughput

0.407

High

852932

ACTZ
Actin-related protein 1

1

5

High-throughput

0.407

High

875208

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.407

High

1069731

Q0E931
GTP-binding protein 1

1

4

High-throughput

0.407

High

1173900

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

17

High-throughput

0.407

High

1175991

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.407

High

1196434

Q4V467
IP10845p

1

2

High-throughput

0.407

High

1234087

Q7JXU4
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.407

High

1234088

NUP50
Nuclear pore complex protein Nup50

1

12

High-throughput

0.407

High

1234094

Q8INH9
Uncharacterized protein, isoform J

1

11

High-throughput

0.407

High

1234095

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

1234096

Q8SY39
ATP-dependent RNA helicase DDX54

1

8

High-throughput

0.407

High

1234103

Q95WY3
Nucleolar protein 56

1

5

High-throughput

0.407

High

1234106

NOG1
Nucleolar GTP-binding protein 1

1

2

High-throughput

0.407

High

1234107

API5
Apoptosis inhibitor 5 homolog

1

1

High-throughput

0.407

High

1234108

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.407

High

1234109

Q9V455
Importin subunit alpha

1

4

High-throughput

0.407

High

1234111

Q9VAH7
N-terminal kinase-like protein

1

3

High-throughput

0.407

High

1234112

Q9VAW3
glutamine--fructose-6-phosphate transaminase

1

1

High-throughput

0.407

High

1234114

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

9

High-throughput

0.407

High

1234116

Q9VDK7
Signal recognition particle subunit SRP72

1

1

High-throughput

0.407

High

1234117

Q9VEH0
Aluminum tubes, isoform A

1

10

High-throughput

0.407

High

1234120

Q9VI53
LD44267p

1

2

High-throughput

0.407

High

1234122

DDX47
ATP-dependent RNA helicase DDX47

1

8

High-throughput

0.407

High

1234126

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.407

High

1234131

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

1234137

Q9VXK5
Putative rRNA methyltransferase

1

2

High-throughput

0.407

High

1234139

Q9VXR5
ATP-binding cassette sub-family F member 2

1

4

High-throughput

0.407

High

1234141

RENT1
Regulator of nonsense transcripts 1 homolog

1

2

High-throughput

0.407

High

1234142

Q9VZ88
AT07585p

1

3

High-throughput

0.407

High

1234143

Q9VZF5
Kinesin-like protein

1

10

High-throughput

0.407

High

1234144

Q9VZQ3
Karst, isoform A

1

8

High-throughput

0.407

High

1234148

Q9W0T7
Dis3 like 3'-5' exoribonuclease 2, isoform A

1

1

High-throughput

0.407

High

1234149

Q9W414
Regulatory particle triple-A ATPase 4

1

4

High-throughput

0.407

High

1234153

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

1

High-throughput

0.407

High

95215

E1JIH4
Uncharacterized protein, isoform D

2

0

High-throughput

0.298

High

1234130

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.265

Low

1234136

Q9VWJ6
FI03615p

1

0

High-throughput

0.249

Low

57163

PTRO
Patronin

1

0

High-throughput

0.232

Low

360537

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

1234091

DYM
Dymeclin

1

0

High-throughput

0.232

Low

1234093

Q86BS3
Chromator, isoform A

1

0

High-throughput

0.232

Low

1234097

Q8SY53
GH11935p

1

0

High-throughput

0.232

Low

1234121

NOC3L
Nucleolar complex protein 3

1

0

High-throughput

0.232

Low

1234127

Q9VM57
Septin interacting protein 2, isoform A

1

0

High-throughput

0.232

Low

1234140

RRP12
RRP12-like protein

1

0

High-throughput

0.232

Low

1234145

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low

1234146

Q9W0E4
Aminopeptidase

1

0

High-throughput

0.232

Low

1234150

Q9W4C1
IP13321p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025