Protein: IFN21
Interferon alpha-21 (IFN-alpha-21) (Interferon alpha-F) (LeIF F)

Gene: IFN21, IFNA21
Organism: Homo sapiens
Interactions: 35
UniProt ID: P01568

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002286 - T cell activation involved in immune response
GO:0002312 - B cell activation involved in immune response
GO:0002323 - natural killer cell activation involved in immune response
GO:0005125 - cytokine activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378219

IFNA1
Interferon alpha-1/13

2

17

High-throughput

0.811

High

378275

IFN14
Interferon alpha-14

2

17

High-throughput

0.811

High

378277

IFNA6
Interferon alpha-6

2

17

High-throughput

0.811

High

378278

IFNA4
Interferon alpha-4

2

18

High-throughput

0.811

High

166732

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

2

11

High-throughput

0.628

High

378279

ISG15
Ubiquitin-like protein ISG15

2

12

High-throughput

0.628

High

378281

IFIT1
Antiviral innate immune response effector IFIT1

2

11

High-throughput

0.628

High

378287

IF44L
Interferon-induced protein 44-like

2

2

High-throughput

0.628

High

378290

CD109
CD109 antigen

2

1

High-throughput

0.628

High

378296

IFI44
Interferon-induced protein 44

2

2

High-throughput

0.628

High

378291

UBR3
E3 ubiquitin-protein ligase UBR3

3

6

High-throughput

0.604

High

378295

PCYXL
Prenylcysteine oxidase 1-like

2

0

High-throughput

0.602

High

378282

IFNA8
Interferon alpha-8

1

17

High-throughput

0.575

High

378284

CCHL
Holocytochrome c-type synthase

2

1

High-throughput

0.574

High

378301

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

2

1

High-throughput

0.574

High

299900

CBPD
Carboxypeptidase D

1

2

High-throughput

0.536

High

378302

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

2

High-throughput

0.536

High

378280

CO4A2

1

0

High-throughput

0.513

High

378283

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

378286

OASL
2'-5'-oligoadenylate synthase-like protein

1

2

High-throughput

0.445

High

378304

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.426

High

378298

HELZ2
3'-5' exoribonuclease HELZ2

1

1

High-throughput

0.407

High

378285

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.328

High

378300

EMC3
ER membrane protein complex subunit 3

2

0

High-throughput

0.328

High

378292

F228A
Protein FAM228A

2

0

High-throughput

0.319

High

378303

AT11B
Phospholipid-transporting ATPase IF

2

0

High-throughput

0.319

High

215478

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.279

Low

378276

MBP
Myelin basic protein

1

0

High-throughput

0.279

Low

378288

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

378293

MSRB3
Methionine-R-sulfoxide reductase B3

1

0

High-throughput

0.279

Low

378294

SUMF1
Formylglycine-generating enzyme

1

0

High-throughput

0.279

Low

378299

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.279

Low

378305

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.279

Low

378289

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.232

Low

378297

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025