Protein: XPC
DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)

Gene: XPC
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q01831

Gene Ontology (top 5):
GO:0000109 - nucleotide-excision repair complex
GO:0000111 - nucleotide-excision repair factor 2 complex
GO:0000404 - heteroduplex DNA loop binding
GO:0000405 - bubble DNA binding
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

931651

RD23B
UV excision repair protein RAD23 homolog B

19

15

Small-scale

0.987

High

931499

RD23A
UV excision repair protein RAD23 homolog A

7

14

Small-scale

0.965

High

622796

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

3

1

Small-scale

0.853

High

654103

XPA
DNA repair protein complementing XP-A cells

2

1

Small-scale

0.768

High

832892

CETN2
Centrin-2

11

4

Small-scale

0.757

High

487204

PARP1
Poly [ADP-ribose] polymerase 1

6

2

Small-scale

0.736

High

181619

CETN3
Centrin-3

5

4

Small-scale

0.716

High

1032842

DDB2
DNA damage-binding protein 2

5

3

Small-scale

0.714

High

588495

RFA2
Replication protein A 32 kDa subunit

5

1

High-throughput

0.714

High

744652

TF2H1
General transcription factor IIH subunit 1

5

3

Small-scale

0.709

High

591602

H2AX
Histone H2AX

4

6

Small-scale

0.694

High

979520

H4
Histone H4

4

1

High-throughput

0.694

High

998226

H31
Histone H3.1

4

2

High-throughput

0.686

High

558054

XRCC6
X-ray repair cross-complementing protein 6

3

3

High-throughput

0.675

High

1032801

SSRP1
FACT complex subunit SSRP1

3

1

High-throughput

0.675

High

1032805

RFA4
Replication protein A 30 kDa subunit

3

1

High-throughput

0.667

High

1032845

H2B1A
Histone H2B type 1-A

3

6

High-throughput

0.667

High

277651

H2AY
Core histone macro-H2A.1

3

8

High-throughput

0.662

High

1032802

CETN1
Centrin-1

3

4

High-throughput

0.662

High

1016783

H33
Histone H3.3

3

2

High-throughput

0.656

High

1032868

WDR76
WD repeat-containing protein 76

3

3

High-throughput

0.656

High

1032844

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

2

Small-scale

0.639

High

446521

DPOLB
DNA polymerase beta

3

0

High-throughput

0.638

High

1032834

APLF
Aprataxin and PNK-like factor

3

0

High-throughput

0.638

High

1032856

SPI2B
Spindlin-2B

3

0

High-throughput

0.638

High

1032874

RN146
E3 ubiquitin-protein ligase RNF146

3

0

High-throughput

0.638

High

1032872

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

3

0

High-throughput

0.634

High

1032895

SP16H
FACT complex subunit SPT16

3

0

High-throughput

0.634

High

502325

H2A1
Histone H2A type 1

2

5

High-throughput

0.628

High

659891

H2B1O
Histone H2B type 1-O

2

6

High-throughput

0.628

High

946756

H2B1D
Histone H2B type 1-D

2

6

High-throughput

0.628

High

1032831

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

2

2

High-throughput

0.628

High

1032857

MACD1
ADP-ribose glycohydrolase MACROD1

2

2

High-throughput

0.628

High

1032880

H2AW
Core histone macro-H2A.2

2

8

High-throughput

0.628

High

1032882

PARP2
Poly [ADP-ribose] polymerase 2

2

1

High-throughput

0.628

High

695244

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.619

High

418945

H2A1B
Histone H2A type 1-B/E

2

5

High-throughput

0.611

High

760428

SDC2
Syndecan-2

2

0

High-throughput

0.602

High

1032830

NAA40
N-alpha-acetyltransferase 40

2

0

High-throughput

0.602

High

501966

H2AZ
Histone H2A.Z

2

6

Small-scale

0.601

High

625319

CSK22
Casein kinase II subunit alpha'

2

0

High-throughput

0.585

High

767986

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.585

High

994990

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.585

High

1032838

SIR6
NAD-dependent protein deacylase sirtuin-6

2

0

High-throughput

0.585

High

128984

MEN1
Menin

2

1

High-throughput

0.584

High

980703

H2B1C
Histone H2B type 1-C/E/F/G/I

2

6

High-throughput

0.584

High

1032797

PO5F1
POU domain, class 5, transcription factor 1

2

1

Small-scale

0.584

High

395936

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

481239

HMGB1
High mobility group protein B1

1

1

Small-scale

0.561

High

1032817

DDB1
DNA damage-binding protein 1

2

0

Small-scale

0.559

High

985135

RL10A
Large ribosomal subunit protein uL1

2

1

High-throughput

0.552

High

345683

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.547

High

1028154

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

228704

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

1

High-throughput

0.536

High

326200

ALX3
Homeobox protein aristaless-like 3

1

1

High-throughput

0.536

High

559313

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

1032818

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.536

High

1032819

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.536

High

1032821

LARP7
La-related protein 7

1

1

High-throughput

0.536

High

1032823

H2A2A
Histone H2A type 2-A

1

5

High-throughput

0.536

High

1032828

H2BWT
Histone H2B type W-T

1

7

High-throughput

0.536

High

1032832

H2A2B
Histone H2A type 2-B

1

5

High-throughput

0.536

High

1032837

H2B3B
Histone H2B type 3-B

1

6

High-throughput

0.536

High

1032866

BAFL
Barrier-to-autointegration factor-like protein

1

1

High-throughput

0.536

High

898610

RL14
Large ribosomal subunit protein eL14

2

0

High-throughput

0.528

High

968883

PRS8
26S proteasome regulatory subunit 8

1

3

Small-scale

0.527

High

1032810

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

132464

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

137433

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.513

High

424392

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.513

High

446920

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

479403

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

552565

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.513

High

601632

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

853999

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

897241

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.513

High

915430

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.513

High

1013044

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1032800

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

1032813

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

1032815

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.513

High

1032835

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

1032836

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.513

High

1032839

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.513

High

1032850

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1032885

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

1032891

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

1032809

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.504

High

1032878

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.493

High

1032888

RT33
Small ribosomal subunit protein mS33

1

0

High-throughput

0.493

High

974235

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

0

High-throughput

0.486

High

1032816

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.486

High

1032852

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.486

High

193367

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.480

High

933617

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.480

High

180789

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.479

High

285637

BAF
Barrier-to-autointegration factor

1

1

Small-scale

0.479

High

326946

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.479

High

403990

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

504883

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.479

High

507853

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

754806

H2B1B
Histone H2B type 1-B

1

6

High-throughput

0.479

High

883507

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

903325

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

Small-scale

0.479

High

1004459

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1032803

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

1032807

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.479

High

1032808

ATR
Serine/threonine-protein kinase ATR

1

1

Small-scale

0.479

High

1032826

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

Small-scale

0.479

High

1032827

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1032840

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1032843

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1032886

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

Small-scale

0.479

High

190877

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

371798

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

400676

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

413652

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

519103

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

532528

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

606649

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

799851

COIL
Coilin

1

0

High-throughput

0.458

High

904613

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

951622

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1015182

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.458

High

1024513

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1032804

CAF1A
Chromatin assembly factor 1 subunit A

1

0

Small-scale

0.458

High

1032806

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1032814

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1032824

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

1032829

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1032841

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1032846

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1032848

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1032861

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1032864

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1032869

CLSPN
Claspin

1

0

Small-scale

0.458

High

1032873

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1032879

BCLF1
Bcl-2-associated transcription factor 1

1

0

High-throughput

0.458

High

1032881

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1032892

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

140874

NOP56
Nucleolar protein 56

1

3

High-throughput

0.445

High

243605

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

2

High-throughput

0.445

High

301016

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.445

High

428717

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

769974

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.445

High

899837

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.445

High

1006343

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.445

High

1032812

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.445

High

1032863

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.445

High

1032876

DDX18
ATP-dependent RNA helicase DDX18

1

1

High-throughput

0.445

High

1032883

MRT4
mRNA turnover protein 4 homolog

1

1

High-throughput

0.445

High

1032889

NOP58
Nucleolar protein 58

1

3

High-throughput

0.445

High

191612

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.426

High

208235

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

257823

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.426

High

303523

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.426

High

344172

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

472659

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.426

High

541956

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.426

High

542465

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.426

High

599751

YBOX3
Y-box-binding protein 3

1

0

High-throughput

0.426

High

611837

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.426

High

612608

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.426

High

615747

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.426

High

686105

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.426

High

692044

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.426

High

810051

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

824107

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.426

High

855045

NOP2
28S rRNA

1

0

High-throughput

0.426

High

859235

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

859575

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.426

High

859788

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.426

High

880288

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.426

High

908693

CCNH
Cyclin-H

1

0

Small-scale

0.426

High

960087

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.426

High

961262

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.426

High

975644

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.426

High

977204

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.426

High

978481

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.426

High

978879

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.426

High

986000

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.426

High

1032798

H11
Histone H1.1

1

0

High-throughput

0.426

High

1032799

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.426

High

1032811

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.426

High

1032820

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.426

High

1032822

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.426

High

1032825

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1032849

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.426

High

1032851

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.426

High

1032853

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1032854

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.426

High

1032855

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.426

High

1032859

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1032860

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.426

High

1032862

HELZ2
3'-5' exoribonuclease HELZ2

1

0

High-throughput

0.426

High

1032865

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.426

High

1032867

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.426

High

1032870

SSF1
Suppressor of SWI4 1 homolog

1

0

High-throughput

0.426

High

1032871

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.426

High

1032875

SPS2L
SPATS2-like protein

1

0

High-throughput

0.426

High

1032877

RBM28
RNA-binding protein 28

1

0

High-throughput

0.426

High

1032884

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

1032887

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.426

High

1032890

RBMX2
RNA-binding motif protein, X-linked 2

1

0

High-throughput

0.426

High

1032893

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.426

High

1032894

TBL2
Transducin beta-like protein 2

1

1

High-throughput

0.407

High

1032847

ZN428
Zinc finger protein 428

1

0

High-throughput

0.279

Low

1032833

CCD71
Coiled-coil domain-containing protein 71

1

0

Small-scale

0.249

Low

1032858

CHOLN
Protein cholesin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025