Protein: TTK
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)

Gene: TTK
Organism: Homo sapiens
Interactions: 167
UniProt ID: P33981

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

708262

TTK
Dual specificity protein kinase TTK

3

16

Small-scale

0.853

High

380093

MAS
Proto-oncogene Mas

2

8

High-throughput

0.811

High

436898

ACM4
Muscarinic acetylcholine receptor M4

2

4

High-throughput

0.726

High

674777

GRPR
Gastrin-releasing peptide receptor

2

4

High-throughput

0.726

High

708264

APJ
Apelin receptor

2

4

High-throughput

0.726

High

708272

NPY2R
Neuropeptide Y receptor type 2

2

4

High-throughput

0.726

High

708356

LPAR4
Lysophosphatidic acid receptor 4

2

8

High-throughput

0.726

High

708375

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

5

High-throughput

0.726

High

431579

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.724

High

171946

GP182
G-protein coupled receptor 182

1

10

High-throughput

0.691

High

598922

FPR1
fMet-Leu-Phe receptor

1

7

High-throughput

0.691

High

674005

V2R
Vasopressin V2 receptor

1

8

High-throughput

0.691

High

708269

GPR12
G-protein coupled receptor 12

1

3

High-throughput

0.691

High

708278

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.691

High

708382

NINL
Ninein-like protein

2

11

High-throughput

0.675

High

708302

KS6A1
Ribosomal protein S6 kinase alpha-1

1

19

High-throughput

0.656

High

708304

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.656

High

625166

CDK2
Cyclin-dependent kinase 2

1

13

Small-scale

0.647

High

708309

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.647

High

672776

CDC27
Cell division cycle protein 27 homolog

3

9

Small-scale

0.640

High

708341

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

4

High-throughput

0.628

High

708373

S39A9
Zinc transporter ZIP9

2

4

High-throughput

0.628

High

126570

P2Y10
Putative P2Y purinoceptor 10

1

10

High-throughput

0.618

High

708266

OPRX
Nociceptin receptor

1

6

High-throughput

0.618

High

708289

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

8

High-throughput

0.618

High

708329

AN36B
Ankyrin repeat domain-containing protein 36B

1

7

High-throughput

0.618

High

128973

PLK4
Serine/threonine-protein kinase PLK4

1

17

High-throughput

0.618

High

226657

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

349921

RASK
GTPase KRas

1

14

High-throughput

0.618

High

384367

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

507879

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

708265

CCNF
Cyclin-F

1

18

High-throughput

0.618

High

708281

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

708282

ACTC
Actin, alpha cardiac muscle 1

1

9

High-throughput

0.618

High

708291

SQSTM
Sequestosome-1

1

5

High-throughput

0.618

High

708294

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.618

High

708299

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.618

High

708310

CE170
Centrosomal protein of 170 kDa

1

8

High-throughput

0.618

High

708326

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.618

High

708352

AURKB
Aurora kinase B

1

16

High-throughput

0.618

High

708362

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.618

High

708363

Q9H4D1
Protein kinase

1

9

High-throughput

0.618

High

708364

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

708372

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.618

High

708376

IBTK
Inhibitor of Bruton tyrosine kinase

1

10

High-throughput

0.618

High

708377

UBQL2
Ubiquilin-2

1

9

High-throughput

0.618

High

154928

NDC80
Kinetochore protein NDC80 homolog

2

11

Small-scale

0.613

High

708340

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

708343

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

708300

PCM1
Pericentriolar material 1 protein

2

2

High-throughput

0.584

High

708368

CENPJ
Centromere protein J

2

7

High-throughput

0.584

High

708380

FZR1
Fizzy-related protein homolog

2

8

Small-scale

0.584

High

708371

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.578

High

386194

P53
Cellular tumor antigen p53

1

9

Small-scale

0.578

High

91429

E7EPI0
Inhibitor of Bruton tyrosine kinase

1

8

High-throughput

0.575

High

708276

VMAT1
Chromaffin granule amine transporter

2

3

High-throughput

0.574

High

708296

I13R2
Interleukin-13 receptor subunit alpha-2

2

7

High-throughput

0.574

High

708325

MIB1
E3 ubiquitin-protein ligase MIB1

1

7

High-throughput

0.553

High

708370

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

5

High-throughput

0.553

High

708337

KNL1
Kinetochore scaffold 1

1

0

Small-scale

0.545

High

116783

KIF2A
Kinesin-like protein KIF2A

1

10

High-throughput

0.536

High

527317

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.536

High

654110

CALX
Calnexin

1

3

High-throughput

0.536

High

708268

UTRN
Utrophin

1

10

High-throughput

0.536

High

708280

RL7A
Large ribosomal subunit protein eL8

1

6

High-throughput

0.536

High

708285

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.536

High

708292

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

708297

ESPL1
Separin

1

1

High-throughput

0.536

High

708330

LRC25
Leucine-rich repeat-containing protein 25

1

1

High-throughput

0.536

High

708342

GEMI5
Gem-associated protein 5

1

5

High-throughput

0.536

High

708360

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.536

High

708366

CHODL
Chondrolectin

1

1

High-throughput

0.536

High

708378

HERC5
E3 ISG15--protein ligase HERC5

1

12

High-throughput

0.536

High

708312

CP135
Centrosomal protein of 135 kDa

2

7

High-throughput

0.533

High

708332

NIN
Ninein

2

16

High-throughput

0.533

High

708307

BOREA
Borealin

1

3

Small-scale

0.520

High

307244

RCBT2
RCC1 and BTB domain-containing protein 2

1

5

High-throughput

0.515

High

311792

TACC2
Transforming acidic coiled-coil-containing protein 2

1

4

Small-scale

0.515

High

708327

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

394207

A4
Amyloid-beta precursor protein

1

12

High-throughput

0.501

High

624787

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.501

High

708267

RAD52
DNA repair protein RAD52 homolog

1

2

Small-scale

0.501

High

708383

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

1

Small-scale

0.501

High

708357

NUF2
Kinetochore protein Nuf2

1

11

Small-scale

0.500

High

661210

S10A2
Protein S100-A2

1

15

High-throughput

0.489

High

708273

PTH2R
Parathyroid hormone 2 receptor

1

3

High-throughput

0.489

High

708321

MTSS2
Protein MTSS 2

1

1

High-throughput

0.489

High

708384

NPTN
Neuroplastin

1

4

High-throughput

0.489

High

708335

SPC24
Kinetochore protein Spc24

1

0

Small-scale

0.479

High

708367

SPC25
Kinetochore protein Spc25

1

0

Small-scale

0.479

High

150876

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

294441

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

295948

MTA2
Metastasis-associated protein MTA2

1

3

High-throughput

0.479

High

305155

UBE4B
Ubiquitin conjugation factor E4 B

1

7

Small-scale

0.479

High

322243

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

369079

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

428044

TBB5
Tubulin beta chain

1

10

Small-scale

0.479

High

443363

VIME
Vimentin

1

20

High-throughput

0.479

High

451376

CLCA
Clathrin light chain A

1

1

High-throughput

0.479

High

518593

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

521755

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

552056

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

575695

VINC
Vinculin

1

2

High-throughput

0.479

High

650486

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.479

High

708270

TISD
mRNA decay activator protein ZFP36L2

1

5

High-throughput

0.479

High

708275

FXR1
RNA-binding protein FXR1

1

19

High-throughput

0.479

High

708277

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

708279

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

708284

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

708286

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.479

High

708287

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

708288

CDC16
Cell division cycle protein 16 homolog

1

10

Small-scale

0.479

High

708290

SMAD4
Mothers against decapentaplegic homolog 4

1

3

Small-scale

0.479

High

708293

CUL3
Cullin-3

1

6

High-throughput

0.479

High

708295

DCTN1
Dynactin subunit 1

1

13

High-throughput

0.479

High

708308

ODFP2
Outer dense fiber protein 2

1

6

High-throughput

0.479

High

708311

CE162
Centrosomal protein of 162 kDa

1

12

High-throughput

0.479

High

708314

FTM
Protein fantom

1

9

High-throughput

0.479

High

708318

SYNE3
Nesprin-3

1

11

High-throughput

0.479

High

708322

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

708323

CNTRL
Centriolin

1

12

High-throughput

0.479

High

708328

CNTRB
Centrobin

1

9

High-throughput

0.479

High

708333

CE120
Centrosomal protein of 120 kDa

1

17

High-throughput

0.479

High

708334

POC1A
POC1 centriolar protein homolog A

1

2

High-throughput

0.479

High

708344

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

708345

HS105
Heat shock protein 105 kDa

1

15

High-throughput

0.479

High

708347

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

708348

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

14

Small-scale

0.479

High

708349

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

14

High-throughput

0.479

High

708358

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.479

High

708359

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.479

High

708361

VP33B
Vacuolar protein sorting-associated protein 33B

1

6

High-throughput

0.479

High

708365

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

708369

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

708381

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.479

High

708346

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

708355

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

708374

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

708298

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.445

High

302484

CE152
Centrosomal protein of 152 kDa

1

6

High-throughput

0.437

High

708263

RFA3
Replication protein A 14 kDa subunit

1

11

High-throughput

0.437

High

708271

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.437

High

708274

VASP
Vasodilator-stimulated phosphoprotein

1

11

High-throughput

0.437

High

708283

PRB3
Basic salivary proline-rich protein 3

1

4

High-throughput

0.437

High

708301

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.437

High

708303

CCDC6
Coiled-coil domain-containing protein 6

1

15

High-throughput

0.437

High

708306

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

708313

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.437

High

708315

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.437

High

708316

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

708317

FBX42
F-box only protein 42

1

9

High-throughput

0.437

High

708320

CE128
Centrosomal protein of 128 kDa

1

13

High-throughput

0.437

High

708324

TAXB1
Tax1-binding protein 1

1

14

High-throughput

0.437

High

708338

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.437

High

708339

PLPR1
Phospholipid phosphatase-related protein type 1

1

1

High-throughput

0.437

High

708350

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

708353

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.437

High

708354

CEP89
Centrosomal protein of 89 kDa

1

8

High-throughput

0.437

High

708379

ANC2
Anaphase-promoting complex subunit 2

1

9

High-throughput

0.437

High

91438

E7EQ69
N-alpha-acetyltransferase 50

1

1

High-throughput

0.407

High

708336

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

708331

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

60150

XIRP2
Xin actin-binding repeat-containing protein 2

1

0

High-throughput

0.269

Low

708305

MOONR
Protein moonraker

1

0

High-throughput

0.249

Low

708319

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

708351

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024