Protein: OAS1
2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (E18/E16) (p46/p42 OAS)

Gene: OAS1
Organism: Homo sapiens
Interactions: 82
UniProt ID: P00973

Gene Ontology (top 5):
GO:0001730 - 2'-5'-oligoadenylate synthetase activity
GO:0003725 - double-stranded RNA binding
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369154

TRI27
Zinc finger protein RFP

5

0

High-throughput

0.694

High

137165

EXOC5
Exocyst complex component 5

4

0

High-throughput

0.679

High

369152

ACTN1
Alpha-actinin-1

3

0

High-throughput

0.654

High

369175

IRF9
Interferon regulatory factor 9

3

2

Small-scale

0.640

High

369203

RUFY1
RUN and FYVE domain-containing protein 1

2

1

High-throughput

0.606

High

369196

HOOK2
Protein Hook homolog 2

2

0

High-throughput

0.580

High

369202

BBS4
BBSome complex member BBS4

2

0

High-throughput

0.580

High

369180

GOGA2
Golgin subfamily A member 2

2

2

High-throughput

0.553

High

369199

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.549

High

369185

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.493

High

369150

RASK
GTPase KRas

1

2

High-throughput

0.479

High

369151

IRF1
Interferon regulatory factor 1

1

2

Small-scale

0.479

High

369160

PML
Protein PML

1

2

High-throughput

0.479

High

224875

BUD23
18S rRNA

1

0

High-throughput

0.460

High

369174

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.460

High

369168

STAT2
Signal transducer and activator of transcription 2

1

0

Small-scale

0.458

High

169378

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.445

High

369153

NCAM1
Neural cell adhesion molecule 1

1

1

High-throughput

0.445

High

369158

GRN
Progranulin

1

1

High-throughput

0.445

High

369171

RAB14
Ras-related protein Rab-14

1

1

High-throughput

0.445

High

369172

RAP1B
Ras-related protein Rap-1b

1

2

High-throughput

0.445

High

369179

ZO1
Tight junction protein 1

1

1

High-throughput

0.445

High

369184

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

369188

LUZP1
Leucine zipper protein 1

1

3

High-throughput

0.445

High

369192

RAB2B
Ras-related protein Rab-2B

1

1

High-throughput

0.445

High

369193

NDRG1
Protein NDRG1

1

1

High-throughput

0.445

High

369195

STAM1
Signal transducing adapter molecule 1

1

1

High-throughput

0.445

High

369200

PRRC1
Protein PRRC1

1

1

High-throughput

0.445

High

369206

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.445

High

369207

SNAG
Gamma-soluble NSF attachment protein

1

1

High-throughput

0.445

High

369214

RBM12
RNA-binding protein 12

1

5

High-throughput

0.445

High

369216

FPRP
Prostaglandin F2 receptor negative regulator

1

1

High-throughput

0.445

High

369217

ZO2
Tight junction protein 2

1

1

High-throughput

0.445

High

369218

NDRG3
Protein NDRG3

1

1

High-throughput

0.445

High

48329

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

0

High-throughput

0.426

High

176633

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.426

High

211468

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

0

High-throughput

0.426

High

226653

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

High-throughput

0.426

High

278793

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.426

High

290824

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.426

High

321074

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.426

High

369155

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.426

High

369156

ITA2
Integrin alpha-2

1

0

High-throughput

0.426

High

369157

OSBP1
Oxysterol-binding protein 1

1

0

High-throughput

0.426

High

369159

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.426

High

369161

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.426

High

369163

PGM1
Phosphoglucomutase-1

1

0

High-throughput

0.426

High

369164

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.426

High

369165

CRK
Adapter molecule crk

1

0

High-throughput

0.426

High

369166

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.426

High

369167

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.426

High

369169

IST1
IST1 homolog

1

0

High-throughput

0.426

High

369170

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.426

High

369173

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.426

High

369176

MMSA
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

1

0

High-throughput

0.426

High

369177

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

0

High-throughput

0.426

High

369178

TF65
Transcription factor p65

1

0

High-throughput

0.426

High

369181

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.426

High

369182

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

369183

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.426

High

369186

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.426

High

369187

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

High-throughput

0.426

High

369190

NXP20
Protein NOXP20

1

0

High-throughput

0.426

High

369191

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.426

High

369194

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

0

High-throughput

0.426

High

369197

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.426

High

369198

PDLI2
PDZ and LIM domain protein 2

1

0

High-throughput

0.426

High

369201

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.426

High

369204

NIBA2
Protein Niban 2

1

0

High-throughput

0.426

High

369205

CNN2
Calponin-2

1

0

High-throughput

0.426

High

369208

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.426

High

369209

OFUT1
GDP-fucose protein O-fucosyltransferase 1

1

0

High-throughput

0.426

High

369210

AMPB
Aminopeptidase B

1

0

High-throughput

0.426

High

369211

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

0

High-throughput

0.426

High

369212

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.426

High

369213

KLC4
Kinesin light chain 4

1

0

High-throughput

0.426

High

369215

OGFR
Opioid growth factor receptor

1

0

High-throughput

0.426

High

369219

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.426

High

369220

FAF1
FAS-associated factor 1

1

0

High-throughput

0.426

High

369221

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

369162

L1CAM
Neural cell adhesion molecule L1

1

0

High-throughput

0.232

Low

369189

CCD25
Coiled-coil domain-containing protein 25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025