Protein: SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (Nucleic acid-binding protein RY-1) (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (U4/U6.U5 tri-snRNP-associated protein 3)

Gene: SNR27, SNRNP27
Organism: Homo sapiens
Interactions: 208
UniProt ID: Q8WVK2

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003676 - nucleic acid binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0046540 - U4/U6 x U5 tri-snRNP complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006588

SRPK2
SRSF protein kinase 2

4

1

High-throughput

0.706

High

1358174

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

3

1

High-throughput

0.667

High

1024725

VIGLN
Vigilin

3

0

High-throughput

0.638

High

691804

MK03
Mitogen-activated protein kinase 3

2

1

High-throughput

0.628

High

1097218

PAK2
Serine/threonine-protein kinase PAK 2

2

2

High-throughput

0.628

High

1358182

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

1

High-throughput

0.628

High

1358196

NAA50
N-alpha-acetyltransferase 50

2

1

High-throughput

0.628

High

1358204

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

1

High-throughput

0.628

High

1358223

SNX6
Sorting nexin-6

2

1

High-throughput

0.628

High

1358176

OTUB1
Ubiquitin thioesterase OTUB1

3

0

High-throughput

0.622

High

974168

RUXG
Small nuclear ribonucleoprotein G

2

3

High-throughput

0.611

High

48372

UBA6
Ubiquitin-like modifier-activating enzyme 6

2

0

High-throughput

0.602

High

211503

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

2

0

High-throughput

0.602

High

215154

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

0

High-throughput

0.602

High

227117

SYNC
Asparagine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

709146

TPP2
Tripeptidyl-peptidase 2

2

0

High-throughput

0.602

High

716389

BLVRB
Flavin reductase

2

0

High-throughput

0.602

High

814551

FEN1
Flap endonuclease 1

2

0

High-throughput

0.602

High

854895

RECQ1
ATP-dependent DNA helicase Q1

2

0

High-throughput

0.602

High

973775

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

991216

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

0

High-throughput

0.602

High

1013086

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

2

0

High-throughput

0.602

High

1053708

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

0

High-throughput

0.602

High

1091781

PP1R8
Nuclear inhibitor of protein phosphatase 1

2

0

High-throughput

0.602

High

1107585

PICAL
Phosphatidylinositol-binding clathrin assembly protein

2

0

High-throughput

0.602

High

1109341

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.602

High

1153726

TOM34
Mitochondrial import receptor subunit TOM34

2

0

High-throughput

0.602

High

1180165

QRIC1
Transcriptional regulator QRICH1

2

0

High-throughput

0.602

High

1234604

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

2

0

High-throughput

0.602

High

1358165

CTBL1
Beta-catenin-like protein 1

2

0

High-throughput

0.602

High

1358170

SYAP1
Synapse-associated protein 1

2

0

High-throughput

0.602

High

1358179

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

2

0

High-throughput

0.602

High

1358180

CAR19
Caspase recruitment domain-containing protein 19

2

0

High-throughput

0.602

High

1358183

QKI
KH domain-containing RNA-binding protein QKI

2

0

High-throughput

0.602

High

1358184

S10AD
Protein S100-A13

2

0

High-throughput

0.602

High

1358187

VRK1
Serine/threonine-protein kinase VRK1

2

0

High-throughput

0.602

High

1358193

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

2

0

High-throughput

0.602

High

1358203

UBE2T
Ubiquitin-conjugating enzyme E2 T

2

0

High-throughput

0.602

High

1358208

RBM12
RNA-binding protein 12

2

0

High-throughput

0.602

High

1358225

RRP44
Exosome complex exonuclease RRP44

2

0

High-throughput

0.602

High

1358227

SBDS
Ribosome maturation protein SBDS

2

0

High-throughput

0.602

High

249640

SNX3
Sorting nexin-3

2

1

High-throughput

0.574

High

255846

USO1
General vesicular transport factor p115

2

1

High-throughput

0.574

High

297112

PAK3
Serine/threonine-protein kinase PAK 3

2

2

High-throughput

0.574

High

322275

GLSK
Glutaminase kidney isoform, mitochondrial

2

1

High-throughput

0.574

High

343621

OXSR1
Serine/threonine-protein kinase OSR1

2

1

High-throughput

0.574

High

690524

KAD4
Adenylate kinase 4, mitochondrial

2

1

High-throughput

0.574

High

1015076

ARF5
ADP-ribosylation factor 5

2

1

High-throughput

0.574

High

1291937

WDR5B
WD repeat-containing protein 5B

2

2

High-throughput

0.574

High

1358194

EIF2A
Eukaryotic translation initiation factor 2A

2

1

High-throughput

0.574

High

1358198

SLK
STE20-like serine/threonine-protein kinase

2

2

High-throughput

0.574

High

1358209

TXLNG
Gamma-taxilin

2

1

High-throughput

0.574

High

1358212

STK26
Serine/threonine-protein kinase 26

2

2

High-throughput

0.574

High

1358234

SAR1B
Small COPII coat GTPase SAR1B

2

2

High-throughput

0.574

High

1311253

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

1

High-throughput

0.573

High

209307

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

2

High-throughput

0.536

High

703663

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

1358218

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

4

High-throughput

0.536

High

1358229

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

4

High-throughput

0.536

High

158662

TYB4Y
Thymosin beta-4, Y-chromosomal

1

0

High-throughput

0.513

High

216762

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

485696

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.513

High

487573

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

573180

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.513

High

770406

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.513

High

890213

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.513

High

902940

DUS3
Dual specificity protein phosphatase 3

1

0

High-throughput

0.513

High

948566

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

956424

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

991379

SUMO1
Small ubiquitin-related modifier 1

1

0

High-throughput

0.513

High

1016356

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1023583

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1026900

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

0

High-throughput

0.513

High

1081637

HSP7E
Heat shock 70 kDa protein 14

1

0

High-throughput

0.513

High

1085139

SCRN1
Secernin-1

1

0

High-throughput

0.513

High

1117615

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

1132856

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.513

High

1137247

CND1
Condensin complex subunit 1

1

0

High-throughput

0.513

High

1142806

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.513

High

1149143

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

1156162

ZYX
Zyxin

1

0

High-throughput

0.513

High

1187010

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1199438

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

0

High-throughput

0.513

High

1270754

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.513

High

1278775

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.513

High

1339107

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.513

High

1356382

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.513

High

1358169

EZH1
Histone-lysine N-methyltransferase EZH1

1

0

High-throughput

0.513

High

1358185

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.513

High

1358189

RBM42
RNA-binding protein 42

1

0

High-throughput

0.513

High

1358190

H2AJ
Histone H2A.J

1

0

High-throughput

0.513

High

1358214

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.513

High

1358222

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1358230

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.513

High

1358232

TNPO3
Transportin-3

1

0

High-throughput

0.513

High

821165

TXLNA
Alpha-taxilin

1

2

High-throughput

0.489

High

975149

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.489

High

1141824

EEA1
Early endosome antigen 1

1

1

High-throughput

0.489

High

286486

WBP4
WW domain-binding protein 4

1

1

High-throughput

0.481

High

372684

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406430

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

889624

CLK2
Dual specificity protein kinase CLK2

1

0

High-throughput

0.460

High

325949

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

335884

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

342983

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

401206

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

904967

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

970838

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

980048

H4
Histone H4

1

0

High-throughput

0.458

High

1117288

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1161572

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1271753

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1327426

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

Small-scale

0.458

High

1328878

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.458

High

1358168

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1358215

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1358231

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

71597

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

3

High-throughput

0.445

High

1132527

NAA30
N-alpha-acetyltransferase 30

1

1

High-throughput

0.445

High

374098

RASN
GTPase NRas

1

2

High-throughput

0.437

High

1358221

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

770457

SPRE
Sepiapterin reductase

1

0

High-throughput

0.426

High

818754

CAPG
Macrophage-capping protein

1

0

High-throughput

0.426

High

884545

SYAC
Alanine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

1036114

MMSA
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

1

0

High-throughput

0.426

High

1116432

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.426

High

1122682

TTL12
Tubulin--tyrosine ligase-like protein 12

1

0

High-throughput

0.426

High

1145299

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.426

High

1251881

CCNI2
Cyclin-I2

1

0

High-throughput

0.426

High

1340604

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

0

High-throughput

0.426

High

1358163

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.426

High

1358178

PDLI2
PDZ and LIM domain protein 2

1

0

High-throughput

0.426

High

1358188

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.426

High

1358200

RANB3
Ran-binding protein 3

1

0

High-throughput

0.426

High

1358224

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.426

High

365769

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.407

High

786345

PGM1
Phosphoglucomutase-1

1

1

High-throughput

0.407

High

959372

RAP1B
Ras-related protein Rap-1b

1

1

High-throughput

0.407

High

1358177

PGM2
Phosphopentomutase

1

1

High-throughput

0.407

High

220703

DENR
Density-regulated protein

2

0

High-throughput

0.328

High

329312

LETM1
Mitochondrial proton/calcium exchanger protein

2

0

High-throughput

0.328

High

360053

NB5R3
NADH-cytochrome b5 reductase 3

2

0

High-throughput

0.328

High

976757

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.328

High

1051815

EF1A2
Elongation factor 1-alpha 2

2

0

High-throughput

0.328

High

1119858

CKAP5
Cytoskeleton-associated protein 5

2

0

High-throughput

0.328

High

1129104

PLSI
Plastin-1

2

0

High-throughput

0.328

High

1133130

LASP1
LIM and SH3 domain protein 1

2

0

High-throughput

0.328

High

1142997

PMVK
Phosphomevalonate kinase

2

0

High-throughput

0.328

High

1154693

VAMP3
Vesicle-associated membrane protein 3

2

0

High-throughput

0.328

High

1204935

MTX3
Metaxin-3

2

0

High-throughput

0.328

High

1358175

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.328

High

1358191

PDC10
Programmed cell death protein 10

2

0

High-throughput

0.328

High

1358197

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

2

0

High-throughput

0.328

High

1358201

ARMT1
Damage-control phosphatase ARMT1

2

0

High-throughput

0.328

High

1358216

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

0

High-throughput

0.328

High

1358228

TLN1
Talin-1

2

0

High-throughput

0.328

High

1358226

LC7L2
Putative RNA-binding protein Luc7-like 2

2

0

High-throughput

0.318

High

162849

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.279

Low

169200

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

240109

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

0

High-throughput

0.279

Low

488069

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

694378

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

720785

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.279

Low

1117006

LAMB3
Laminin subunit beta-3

1

0

High-throughput

0.279

Low

1150059

MARE2
Microtubule-associated protein RP/EB family member 2

1

0

High-throughput

0.279

Low

1162444

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

1218113

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1340081

ATLA2
Atlastin-2

1

0

High-throughput

0.279

Low

1358164

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

1358166

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.279

Low

1358171

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1358172

EFHD2
EF-hand domain-containing protein D2

1

0

High-throughput

0.279

Low

1358181

PRRC1
Protein PRRC1

1

0

High-throughput

0.279

Low

1358211

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

1358219

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.279

Low

1358220

ANR50
Ankyrin repeat domain-containing protein 50

1

0

High-throughput

0.279

Low

1358233

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

1358235

S23IP
SEC23-interacting protein

1

0

High-throughput

0.279

Low

157662

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

1290614

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

1358173

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1358195

WNK3
Serine/threonine-protein kinase WNK3

1

0

High-throughput

0.249

Low

1358210

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.249

Low

349692

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.232

Low

357964

CYB5
Cytochrome b5

1

0

High-throughput

0.232

Low

360206

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.232

Low

628368

CD33
Myeloid cell surface antigen CD33

1

0

High-throughput

0.232

Low

877362

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.232

Low

888727

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

0

High-throughput

0.232

Low

916186

BIEA
Biliverdin reductase A

1

0

High-throughput

0.232

Low

921509

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.232

Low

952264

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.232

Low

1060197

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.232

Low

1062832

QOR
Quinone oxidoreductase

1

0

High-throughput

0.232

Low

1063993

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.232

Low

1144784

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.232

Low

1200493

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.232

Low

1218792

BROX
BRO1 domain-containing protein BROX

1

0

High-throughput

0.232

Low

1358167

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

0

High-throughput

0.232

Low

1358186

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.232

Low

1358192

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

0

High-throughput

0.232

Low

1358199

AMPB
Aminopeptidase B

1

0

High-throughput

0.232

Low

1358202

POPD2
Popeye domain-containing protein 2

1

0

High-throughput

0.232

Low

1358205

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.232

Low

1358206

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.232

Low

1358207

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1358213

I36RA
Interleukin-36 receptor antagonist protein

1

0

High-throughput

0.232

Low

1358217

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025