Protein: KS6A4
Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)

Gene: KS6A4, RPS6KA4
Organism: Homo sapiens
Interactions: 84
UniProt ID: O75676

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001818 - negative regulation of cytokine production
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

272871

MK14
Mitogen-activated protein kinase 14

10

20

Small-scale

0.979

High

272899

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

4

15

High-throughput

0.903

High

272850

MK01
Mitogen-activated protein kinase 1

4

20

Small-scale

0.893

High

272872

CDC37
Hsp90 co-chaperone Cdc37

3

13

High-throughput

0.871

High

272843

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.811

High

272844

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.811

High

272858

CSK2B
Casein kinase II subunit beta

2

8

High-throughput

0.811

High

272841

KPCB
Protein kinase C beta type

2

17

High-throughput

0.737

High

149805

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.691

High

272836

TNNC2
Troponin C, skeletal muscle

1

1

High-throughput

0.691

High

272851

MK04
Mitogen-activated protein kinase 4

1

20

High-throughput

0.691

High

272862

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

10

High-throughput

0.691

High

272868

KS6A1
Ribosomal protein S6 kinase alpha-1

1

15

High-throughput

0.691

High

272869

IKBB
NF-kappa-B inhibitor beta

1

7

High-throughput

0.691

High

272870

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.691

High

272884

CDK20
Cyclin-dependent kinase 20

1

4

High-throughput

0.691

High

272849

MK03
Mitogen-activated protein kinase 3

1

20

Small-scale

0.665

High

157844

KLF11
Krueppel-like factor 11

1

6

High-throughput

0.665

High

272896

KLDC3
Kelch domain-containing protein 3

2

3

High-throughput

0.628

High

272861

SNTB2
Beta-2-syntrophin

1

17

High-throughput

0.618

High

272882

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

272901

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.618

High

272904

ANLN
Anillin

1

0

High-throughput

0.586

High

217851

PRKY
Putative serine/threonine-protein kinase PRKY

1

16

High-throughput

0.575

High

272876

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

272877

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

272878

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.575

High

272832

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.536

High

272833

DCTN3
Dynactin subunit 3

1

1

High-throughput

0.536

High

272838

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.536

High

272840

ANXA1
Annexin A1

1

5

High-throughput

0.536

High

272853

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.536

High

272854

OX2G
OX-2 membrane glycoprotein

1

3

High-throughput

0.536

High

272873

H2A2C
Histone H2A type 2-C

1

8

High-throughput

0.536

High

272874

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.536

High

272879

H2A2A
Histone H2A type 2-A

1

8

High-throughput

0.536

High

272883

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

12

High-throughput

0.536

High

272889

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

272892

TCPQM
T-complex protein 1 subunit theta-like 2

1

17

High-throughput

0.536

High

272895

NPAS1
Neuronal PAS domain-containing protein 1

1

5

High-throughput

0.536

High

272902

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.536

High

272908

CLC4A
C-type lectin domain family 4 member A

1

3

High-throughput

0.536

High

272910

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

272845

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.515

High

245655

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

272834

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

272842

H10
Histone H1.0

1

0

High-throughput

0.513

High

272866

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

272891

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

272897

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

272900

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

272907

SCOC
Short coiled-coil protein

1

0

High-throughput

0.513

High

272835

FOS
Protein c-Fos

1

6

Small-scale

0.501

High

272846

CREB1
Cyclic AMP-responsive element-binding protein 1

1

5

Small-scale

0.501

High

272855

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

61665

CDHR4
Cadherin-related family member 4

1

2

High-throughput

0.489

High

272837

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

272885

KLH34
Kelch-like protein 34

1

4

High-throughput

0.489

High

272887

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

272898

DNAI2
Dynein axonemal intermediate chain 2

1

4

High-throughput

0.489

High

272909

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.489

High

272847

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

272848

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

272852

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

272856

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.479

High

272857

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

272860

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

272863

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.479

High

272867

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

272875

WASC4
WASH complex subunit 4

1

2

High-throughput

0.479

High

272888

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

272890

SH3K1
SH3 domain-containing kinase-binding protein 1

1

10

High-throughput

0.479

High

272894

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

272903

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

272905

AKA7G
A-kinase anchor protein 7 isoform gamma

1

5

High-throughput

0.479

High

272906

HECW2
E3 ubiquitin-protein ligase HECW2

1

10

High-throughput

0.479

High

272859

E2F1
Transcription factor E2F1

1

1

High-throughput

0.445

High

272864

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

272865

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

272893

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.445

High

272880

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.437

High

272881

PKHG7
Pleckstrin homology domain-containing family G member 7

1

9

High-throughput

0.407

High

272839

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.279

Low

272886

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024