Protein: LCOR
Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)

Gene: LCOR
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q96JN0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001222 - transcription corepressor binding
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1103319

CTBP1
C-terminal-binding protein 1

11

5

Small-scale

0.759

High

941521

CTBP2
C-terminal-binding protein 2

8

5

Small-scale

0.753

High

1155665

EZH2
Histone-lysine N-methyltransferase EZH2

5

5

High-throughput

0.706

High

210330

PHF1
PHD finger protein 1

3

2

High-throughput

0.667

High

1137460

SUZ12
Polycomb protein SUZ12

4

0

High-throughput

0.664

High

1368792

EZH1
Histone-lysine N-methyltransferase EZH1

3

5

High-throughput

0.662

High

1395305

HDAC6
Protein deacetylase HDAC6

2

3

Small-scale

0.629

High

1066445

RBBP4
Histone-binding protein RBBP4

2

1

High-throughput

0.628

High

1395277

KLDC3
Kelch domain-containing protein 3

2

1

High-throughput

0.628

High

1395320

MTF2
Metal-response element-binding transcription factor 2

2

2

High-throughput

0.628

High

285416

EED
Polycomb protein EED

3

0

High-throughput

0.622

High

1213582

PHF19
PHD finger protein 19

2

2

High-throughput

0.611

High

1158160

MK14
Mitogen-activated protein kinase 14

2

0

High-throughput

0.602

High

1277213

POGZ
Pogo transposable element with ZNF domain

2

0

High-throughput

0.602

High

1365811

ZN516
Zinc finger protein 516

2

0

High-throughput

0.602

High

1371602

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

0

High-throughput

0.602

High

1158958

RBBP7
Histone-binding protein RBBP7

2

1

High-throughput

0.601

High

396720

ESR1
Estrogen receptor

1

2

Small-scale

0.586

High

552352

ADT3
ADP/ATP translocase 3

2

0

High-throughput

0.585

High

1385733

BIRC7
Baculoviral IAP repeat-containing protein 7

2

0

High-throughput

0.580

High

1007206

TCPB
T-complex protein 1 subunit beta

2

1

High-throughput

0.578

High

1060905

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

2

High-throughput

0.574

High

188342

HDAC3
Histone deacetylase 3

1

2

Small-scale

0.561

High

1395274

KLF6
Krueppel-like factor 6

1

0

Small-scale

0.549

High

287995

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.541

High

443925

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

High-throughput

0.541

High

484204

PGFRB
Platelet-derived growth factor receptor beta

1

1

High-throughput

0.541

High

639800

TAF1
Transcription initiation factor TFIID subunit 1

1

1

High-throughput

0.541

High

862937

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.541

High

923624

TTC3
E3 ubiquitin-protein ligase TTC3

1

1

High-throughput

0.541

High

1202604

TNI3K
Serine/threonine-protein kinase TNNI3K

1

1

High-throughput

0.541

High

1370298

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.541

High

1395273

RANB9
Ran-binding protein 9

1

1

High-throughput

0.541

High

1395295

TBG2
Tubulin gamma-2 chain

1

1

High-throughput

0.541

High

899530

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.536

High

1258262

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

1

High-throughput

0.536

High

520293

ANDR
Androgen receptor

1

2

Small-scale

0.527

High

124828

AIP
AH receptor-interacting protein

1

0

High-throughput

0.518

High

140406

SDCB1
Syntenin-1

1

0

High-throughput

0.518

High

156653

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

0

High-throughput

0.518

High

192628

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.518

High

230836

EXTL3
Exostosin-like 3

1

0

High-throughput

0.518

High

279867

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.518

High

289659

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.518

High

319013

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.518

High

402660

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.518

High

405322

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.518

High

533737

CLUS
Clusterin

1

0

High-throughput

0.518

High

566007

EF2
Elongation factor 2

1

0

High-throughput

0.518

High

578701

GLNA
Glutamine synthetase

1

0

High-throughput

0.518

High

657919

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.518

High

685050

DNMT1
DNA

1

0

High-throughput

0.518

High

700942

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.518

High

833597

UBA7
Ubiquitin-like modifier-activating enzyme 7

1

0

High-throughput

0.518

High

891284

GSK3A
Glycogen synthase kinase-3 alpha

1

0

High-throughput

0.518

High

898517

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.518

High

911860

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.518

High

953038

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.518

High

971883

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.518

High

1038579

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

0

High-throughput

0.518

High

1093292

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.518

High

1102225

ATM
Serine-protein kinase ATM

1

0

High-throughput

0.518

High

1122689

TTL12
Tubulin--tyrosine ligase-like protein 12

1

0

High-throughput

0.518

High

1125962

GAMT
Guanidinoacetate N-methyltransferase

1

0

High-throughput

0.518

High

1129364

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

High-throughput

0.518

High

1287919

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.518

High

1288688

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

0

High-throughput

0.518

High

1337150

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.518

High

1337577

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.518

High

1361448

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.518

High

1395275

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.518

High

1395280

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

0

High-throughput

0.518

High

1395282

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.518

High

1395283

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.518

High

1395284

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.518

High

1395289

TARA
TRIO and F-actin-binding protein

1

0

High-throughput

0.518

High

1395290

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.518

High

1395296

ZHANG
CREB/ATF bZIP transcription factor

1

0

High-throughput

0.518

High

1395300

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.518

High

1395311

SRGEF
Secretion-regulating guanine nucleotide exchange factor

1

0

High-throughput

0.518

High

1395312

MED13
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.518

High

1395324

CABIN
Calcineurin-binding protein cabin-1

1

0

High-throughput

0.518

High

59223

A2ABF9
[histone H3]-lysine(9) N-methyltransferase

1

2

High-throughput

0.515

High

1367925

RORB
Nuclear receptor ROR-beta

1

2

High-throughput

0.515

High

601808

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

775713

DEK
Protein DEK

1

0

High-throughput

0.513

High

1013094

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1054767

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1134331

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

1134683

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

1163139

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1395278

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.513

High

1395279

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.513

High

1395288

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

1395301

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.513

High

1395308

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.513

High

1395319

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

543531

VDR
Vitamin D3 receptor

1

3

Small-scale

0.501

High

941040

HDAC4
Histone deacetylase 4

1

3

Small-scale

0.501

High

1109990

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.501

High

270582

LRP4
Low-density lipoprotein receptor-related protein 4

1

2

High-throughput

0.494

High

276222

LRRN2
Leucine-rich repeat neuronal protein 2

1

1

High-throughput

0.494

High

323901

SC31A
Protein transport protein Sec31A

1

2

High-throughput

0.494

High

1218531

ATRN1
Attractin-like protein 1

1

1

High-throughput

0.494

High

1220736

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.494

High

1395271

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.494

High

1395293

LRRC4
Leucine-rich repeat-containing protein 4

1

1

High-throughput

0.494

High

1395302

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

2

High-throughput

0.494

High

1395306

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

5

High-throughput

0.494

High

172176

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

0

High-throughput

0.493

High

821509

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.489

High

876120

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.489

High

1201924

Q58EY0
RAR related orphan receptor B isoform 1

1

2

High-throughput

0.481

High

65640

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

1

2

High-throughput

0.479

High

143192

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

474211

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

607007

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

674292

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.479

High

887126

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.479

High

1048063

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1087946

NFIA
Nuclear factor 1 A-type

1

5

High-throughput

0.479

High

1097492

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1133606

NFIX
Nuclear factor 1 X-type

1

5

High-throughput

0.479

High

1338900

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

828900

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

980149

H4
Histone H4

1

0

High-throughput

0.458

High

1085606

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

1252562

AEBP2
Zinc finger protein AEBP2

1

0

High-throughput

0.458

High

1369249

JARD2
Protein Jumonji

1

0

High-throughput

0.458

High

1395310

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1395317

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

1395318

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1395269

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

2

High-throughput

0.457

High

138746

IMA4
Importin subunit alpha-4

1

1

High-throughput

0.445

High

142604

IMA3
Importin subunit alpha-3

1

1

High-throughput

0.445

High

1395291

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.445

High

1395294

CBX8
Chromobox protein homolog 8

1

2

High-throughput

0.445

High

1395313

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

1

High-throughput

0.445

High

637056

VATB2
V-type proton ATPase subunit B, brain isoform

1

1

High-throughput

0.439

High

1033153

EWS
RNA-binding protein EWS

1

0

High-throughput

0.438

High

521860

H14
Histone H1.4

1

0

High-throughput

0.426

High

623634

TFEB
Transcription factor EB

1

0

High-throughput

0.426

High

770041

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.426

High

855726

CRK
Adapter molecule crk

1

0

High-throughput

0.426

High

984495

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.426

High

1162111

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

0

High-throughput

0.426

High

1337409

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

1395316

CDYL
Chromodomain Y-like protein

1

0

High-throughput

0.426

High

404329

GCR
Glucocorticoid receptor

1

2

Small-scale

0.408

High

1093922

TRAF1
TNF receptor-associated factor 1

3

0

High-throughput

0.352

High

720521

AMRP
Alpha-2-macroglobulin receptor-associated protein

2

0

High-throughput

0.328

High

1395286

ZY11B
Protein zyg-11 homolog B

2

0

High-throughput

0.328

High

1395322

ASB3
Ankyrin repeat and SOCS box protein 3

2

0

High-throughput

0.328

High

1340311

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1063530

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.299

High

131496

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.282

High

163584

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.282

High

219350

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.282

High

284022

CAH11
Carbonic anhydrase-related protein 11

1

0

High-throughput

0.282

High

333702

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.282

High

390932

TRFE
Serotransferrin

1

0

High-throughput

0.282

High

407771

VWF
von Willebrand factor

1

0

High-throughput

0.282

High

426032

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

High-throughput

0.282

High

460862

CATB
Cathepsin B

1

0

High-throughput

0.282

High

472343

CFAH
Complement factor H

1

0

High-throughput

0.282

High

505871

PA24B
Cytosolic phospholipase A2 beta

1

0

High-throughput

0.282

High

547191

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.282

High

609324

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.282

High

614722

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.282

High

646914

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.282

High

647395

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.282

High

724158

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.282

High

801468

HSPA9
Stress-70 protein, mitochondrial

1

0

High-throughput

0.282

High

866528

RPGP1
Rap1 GTPase-activating protein 1

1

0

High-throughput

0.282

High

870189

GLIP1
Glioma pathogenesis-related protein 1

1

0

High-throughput

0.282

High

895331

GATM
Glycine amidinotransferase, mitochondrial

1

0

High-throughput

0.282

High

914851

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

1

0

High-throughput

0.282

High

945587

FBXW4
F-box/WD repeat-containing protein 4

1

0

High-throughput

0.282

High

983554

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

High-throughput

0.282

High

1005712

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.282

High

1006215

CNTP1
Contactin-associated protein 1

1

0

High-throughput

0.282

High

1046907

FOLH1
Glutamate carboxypeptidase 2

1

0

High-throughput

0.282

High

1061277

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.282

High

1083142

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.282

High

1088203

MERTK
Tyrosine-protein kinase Mer

1

0

High-throughput

0.282

High

1101471

KCAB2
Voltage-gated potassium channel subunit beta-2

1

0

High-throughput

0.282

High

1117546

ENPP2
Autotaxin

1

0

High-throughput

0.282

High

1123763

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.282

High

1127555

SPRL1
SPARC-like protein 1

1

0

High-throughput

0.282

High

1157412

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.282

High

1162764

KGUA
Guanylate kinase

1

0

High-throughput

0.282

High

1212683

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.282

High

1276404

GLUCM
D-glutamate cyclase, mitochondrial

1

0

High-throughput

0.282

High

1287636

ACOT1
Acyl-coenzyme A thioesterase 1

1

0

High-throughput

0.282

High

1308801

NAV3
Neuron navigator 3

1

0

High-throughput

0.282

High

1315772

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.282

High

1315945

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.282

High

1328549

NGEF
Ephexin-1

1

0

High-throughput

0.282

High

1330596

F86B1
Putative protein N-methyltransferase FAM86B1

1

0

High-throughput

0.282

High

1337457

DEN6B
Protein DENND6B

1

0

High-throughput

0.282

High

1369095

NRCAM
Neuronal cell adhesion molecule

1

0

High-throughput

0.282

High

1385133

MOAP1
Modulator of apoptosis 1

1

0

High-throughput

0.282

High

1390673

STALP
AMSH-like protease

1

0

High-throughput

0.282

High

1395270

GD1L1
Ganglioside-induced differentiation-associated protein 1-like 1

1

0

High-throughput

0.282

High

1395272

FMNL2
Formin-like protein 2

1

0

High-throughput

0.282

High

1395281

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.282

High

1395285

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.282

High

1395287

CYRIA
CYFIP-related Rac1 interactor A

1

0

High-throughput

0.282

High

1395297

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.282

High

1395298

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.282

High

1395303

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

0

High-throughput

0.282

High

1395304

STX18
Syntaxin-18

1

0

High-throughput

0.282

High

1395307

PKHB1
Pleckstrin homology domain-containing family B member 1

1

0

High-throughput

0.282

High

1395309

IF172
Intraflagellar transport protein 172 homolog

1

0

High-throughput

0.282

High

1395314

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.282

High

1395315

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

0

High-throughput

0.282

High

1395323

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

0

High-throughput

0.282

High

705513

GRN
Progranulin

1

0

High-throughput

0.279

Low

956225

RAB4B
Ras-related protein Rab-4B

1

0

High-throughput

0.279

Low

984651

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.279

Low

1330773

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.279

Low

1395299

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.279

Low

346196

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

380124

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.238

Low

516904

ECE2
Endothelin-converting enzyme 2

1

0

High-throughput

0.238

Low

1217425

OBSCN
Obscurin

1

0

High-throughput

0.232

Low

1253156

NBEL2
Neurobeachin-like protein 2

1

0

High-throughput

0.232

Low

1287767

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

1395276

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.232

Low

1395292

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low

1395321

PRC2C
Protein PRRC2C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025