Protein: TTP
mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)

Gene: TTP, ZFP36
Organism: Homo sapiens
Interactions: 166
UniProt ID: P26651

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

516366

PABP1
Polyadenylate-binding protein 1

2

5

Small-scale

0.800

High

644231

1433B
14-3-3 protein beta/alpha

3

17

Small-scale

0.667

High

61310

CNOT1
CCR4-NOT transcription complex subunit 1

2

3

Small-scale

0.621

High

582074

NUCL
Nucleolin

1

5

Small-scale

0.621

High

317653

CNOT4
CCR4-NOT transcription complex subunit 4

1

2

High-throughput

0.618

High

644228

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

6

High-throughput

0.618

High

644240

TIAR
Nucleolysin TIAR

1

4

High-throughput

0.618

High

644254

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

7

High-throughput

0.618

High

644287

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

3

High-throughput

0.618

High

644288

RAVR1
Ribonucleoprotein PTB-binding 1

1

7

High-throughput

0.618

High

644303

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.618

High

644322

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

1

High-throughput

0.618

High

644329

RC3H2
Roquin-2

1

6

High-throughput

0.618

High

644332

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

9

High-throughput

0.618

High

644334

WDR6
tRNA

1

6

High-throughput

0.618

High

644340

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

11

High-throughput

0.618

High

644344

Z3H7B
Zinc finger CCCH domain-containing protein 7B

1

3

High-throughput

0.618

High

644360

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

9

High-throughput

0.618

High

644336

DCP1A
mRNA-decapping enzyme 1A

2

3

Small-scale

0.611

High

644235

MAPK2
MAP kinase-activated protein kinase 2

2

2

Small-scale

0.602

High

644289

DCP1B
mRNA-decapping enzyme 1B

2

5

Small-scale

0.586

High

644355

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.586

High

644307

EDC3
Enhancer of mRNA-decapping protein 3

2

0

Small-scale

0.585

High

264271

GGYF1
GRB10-interacting GYF protein 1

2

2

Small-scale

0.584

High

644227

1433T
14-3-3 protein theta

2

17

Small-scale

0.584

High

644310

CNO6L
CCR4-NOT transcription complex subunit 6-like

2

4

Small-scale

0.584

High

644343

CNOT8
CCR4-NOT transcription complex subunit 8

2

6

Small-scale

0.584

High

644346

CNOT7
CCR4-NOT transcription complex subunit 7

2

6

Small-scale

0.584

High

644350

CNOT6
CCR4-NOT transcription complex subunit 6

2

5

Small-scale

0.584

High

644290

XRN1
5'-3' exoribonuclease 1

2

1

Small-scale

0.584

High

644243

MTG8
Protein CBFA2T1

2

0

High-throughput

0.580

High

644233

NU214
Nuclear pore complex protein Nup214

1

2

Small-scale

0.573

High

352501

TNFA
Tumor necrosis factor

2

0

Small-scale

0.569

High

644237

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

Small-scale

0.561

High

644250

FHL3
Four and a half LIM domains protein 3

1

2

High-throughput

0.560

High

644264

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

2

0

Small-scale

0.559

High

644232

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.552

High

644306

SH3K1
SH3 domain-containing kinase-binding protein 1

1

3

Small-scale

0.552

High

644229

HXC9
Homeobox protein Hox-C9

1

1

High-throughput

0.541

High

644236

ANM2
Protein arginine N-methyltransferase 2

1

2

High-throughput

0.541

High

644258

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

644285

DCP2
m7GpppN-mRNA hydrolase

1

1

Small-scale

0.536

High

644242

1433F
14-3-3 protein eta

1

17

Small-scale

0.527

High

443345

VIME
Vimentin

1

1

High-throughput

0.515

High

644276

EDC4
Enhancer of mRNA-decapping protein 4

1

0

Small-scale

0.513

High

644239

CDK6
Cyclin-dependent kinase 6

1

4

Small-scale

0.501

High

644274

A16L1
Autophagy-related protein 16-1

1

0

Small-scale

0.500

High

644286

ZDH17
Palmitoyltransferase ZDHHC17

1

3

High-throughput

0.494

High

644305

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.486

High

644328

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.486

High

636246

DNJB1
DnaJ homolog subfamily B member 1

1

2

Small-scale

0.481

High

644269

EXOS6
Exosome complex component MTR3

1

1

High-throughput

0.481

High

394151

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

50005

MEX3A
RNA-binding protein MEX3A

1

14

High-throughput

0.479

High

64790

TBKB1
TANK-binding kinase 1-binding protein 1

1

2

High-throughput

0.479

High

87455

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

2

High-throughput

0.479

High

162421

XPO1
Exportin-1

1

4

High-throughput

0.479

High

164788

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.479

High

166209

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

177202

HDAC3
Histone deacetylase 3

1

2

Small-scale

0.479

High

237166

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

243299

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

257316

CNOT3
CCR4-NOT transcription complex subunit 3

1

8

High-throughput

0.479

High

257565

ANR17
Ankyrin repeat domain-containing protein 17

1

2

High-throughput

0.479

High

328736

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

416934

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.479

High

438914

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

High-throughput

0.479

High

587431

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.479

High

632610

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.479

High

640328

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.479

High

644230

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

644234

PRC2A
Protein PRRC2A

1

7

High-throughput

0.479

High

644241

OTUD4
OTU domain-containing protein 4

1

4

High-throughput

0.479

High

644246

TRAF2
TNF receptor-associated factor 2

1

2

Small-scale

0.479

High

644247

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

644248

CUL4B
Cullin-4B

1

3

High-throughput

0.479

High

644249

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.479

High

644251

UBP2L
Ubiquitin-associated protein 2-like

1

4

High-throughput

0.479

High

644252

PUM1
Pumilio homolog 1

1

4

High-throughput

0.479

High

644253

R3HD1
R3H domain-containing protein 1

1

8

High-throughput

0.479

High

644257

TRIP6
Thyroid receptor-interacting protein 6

1

2

High-throughput

0.479

High

644259

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

644260

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

8

High-throughput

0.479

High

644261

KIF7
Kinesin-like protein KIF7

1

1

High-throughput

0.479

High

644262

LSM12
Protein LSM12

1

1

High-throughput

0.479

High

644265

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.479

High

644266

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

2

High-throughput

0.479

High

644267

PRC2B
Protein PRRC2B

1

5

High-throughput

0.479

High

644270

OTUD3
OTU domain-containing protein 3

1

4

Small-scale

0.479

High

644271

TUT4
Terminal uridylyltransferase 4

1

1

High-throughput

0.479

High

644272

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

644273

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

3

High-throughput

0.479

High

644277

CEP85
Centrosomal protein of 85 kDa

1

2

High-throughput

0.479

High

644278

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

644280

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.479

High

644281

PATL1
Protein PAT1 homolog 1

1

3

High-throughput

0.479

High

644282

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

644283

GPBP1
Vasculin

1

2

High-throughput

0.479

High

644284

MEX3D
RNA-binding protein MEX3D

1

9

High-throughput

0.479

High

644292

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

644293

PUM2
Pumilio homolog 2

1

4

High-throughput

0.479

High

644294

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.479

High

644295

HDAC7
Histone deacetylase 7

1

5

Small-scale

0.479

High

644297

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

644298

CNOT9
CCR4-NOT transcription complex subunit 9

1

6

High-throughput

0.479

High

644299

LAR4B
La-related protein 4B

1

1

High-throughput

0.479

High

644300

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

Small-scale

0.479

High

644301

RENT1
Regulator of nonsense transcripts 1

1

3

High-throughput

0.479

High

644302

FUBP2
Far upstream element-binding protein 2

1

12

Small-scale

0.479

High

644308

FUBP3
Far upstream element-binding protein 3

1

12

High-throughput

0.479

High

644309

ASPP1
Apoptosis-stimulating of p53 protein 1

1

2

High-throughput

0.479

High

644312

ATX2
Ataxin-2

1

4

High-throughput

0.479

High

644313

LZTS2
Leucine zipper putative tumor suppressor 2

1

1

High-throughput

0.479

High

644314

TRI56
E3 ubiquitin-protein ligase TRIM56

1

9

High-throughput

0.479

High

644317

LS14B
Protein LSM14 homolog B

1

6

High-throughput

0.479

High

644319

YTHD1
YTH domain-containing family protein 1

1

5

High-throughput

0.479

High

644320

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

High-throughput

0.479

High

644321

TB182
182 kDa tankyrase-1-binding protein

1

5

High-throughput

0.479

High

644324

ESRP2
Epithelial splicing regulatory protein 2

1

7

High-throughput

0.479

High

644325

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

644326

CNO10
CCR4-NOT transcription complex subunit 10

1

1

High-throughput

0.479

High

644327

AGO3
Protein argonaute-3

1

5

High-throughput

0.479

High

644330

MOV10
Helicase MOV-10

1

3

High-throughput

0.479

High

644335

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

4

High-throughput

0.479

High

644337

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

644338

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

1

High-throughput

0.479

High

644339

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.479

High

644341

CNOT2
CCR4-NOT transcription complex subunit 2

1

5

High-throughput

0.479

High

644342

NYNRI
Protein NYNRIN

1

2

High-throughput

0.479

High

644345

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

644347

AGO2
Protein argonaute-2

1

5

High-throughput

0.479

High

644348

CNO11
CCR4-NOT transcription complex subunit 11

1

1

High-throughput

0.479

High

644349

AGO1
Protein argonaute-1

1

5

High-throughput

0.479

High

644352

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

6

High-throughput

0.479

High

644353

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

3

High-throughput

0.479

High

644354

R3HD2
R3H domain-containing protein 2

1

6

High-throughput

0.479

High

644356

PRC2C
Protein PRRC2C

1

5

High-throughput

0.479

High

644357

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

644358

NDK7
Nucleoside diphosphate kinase homolog 7

1

1

High-throughput

0.479

High

644361

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

2

Small-scale

0.479

High

644323

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

0

Small-scale

0.460

High

64655

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.458

High

147316

DPYL4
Dihydropyrimidinase-related protein 4

1

0

High-throughput

0.458

High

575279

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

644244

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.458

High

644245

TROAP
Tastin

1

0

High-throughput

0.458

High

644255

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

644268

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

644304

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.458

High

644311

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

644315

TCHP
Trichoplein keratin filament-binding protein

1

0

High-throughput

0.458

High

644331

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.458

High

644333

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.458

High

644351

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.458

High

644359

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.458

High

644256

SF01
Splicing factor 1

1

5

High-throughput

0.457

High

644238

F193A
Protein FAM193A

1

1

High-throughput

0.437

High

644318

K1671
Uncharacterized protein KIAA1671

1

1

High-throughput

0.437

High

644275

PRR5L
Proline-rich protein 5-like

1

0

Small-scale

0.288

High

557433

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.268

Low

644296

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

546647

B4GT1
Beta-1,4-galactosyltransferase 1

1

0

Small-scale

0.249

Low

644263

TTC31
Tetratricopeptide repeat protein 31

1

0

High-throughput

0.249

Low

644279

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

644291

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.249

Low

644316

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024