Protein: OPA1
Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)]

Gene: OPA1
Organism: Homo sapiens
Interactions: 195
UniProt ID: O60313

Gene Ontology (top 5):
GO:0000266 - mitochondrial fission
GO:0000287 - magnesium ion binding
GO:0001843 - neural tube closure
GO:0003924 - GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

245429

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

4

4

High-throughput

0.691

High

240216

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

245394

SEGN
Secretagogin

3

0

High-throughput

0.638

High

245386

SCN2B
Sodium channel regulatory subunit beta-2

4

4

High-throughput

0.630

High

245413

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

0

High-throughput

0.613

High

245401

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

245464

CUL3
Cullin-3

2

2

High-throughput

0.611

High

245435

VIPR2
Vasoactive intestinal polypeptide receptor 2

3

1

High-throughput

0.604

High

245404

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.602

High

245502

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

245549

GID8
Glucose-induced degradation protein 8 homolog

2

0

High-throughput

0.602

High

245475

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

9

Small-scale

0.588

High

245398

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.584

High

245411

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.584

High

245453

RHOB
Rho-related GTP-binding protein RhoB

2

3

High-throughput

0.584

High

245490

MAVS
Mitochondrial antiviral-signaling protein

2

3

Small-scale

0.584

High

245507

AKAP1
A-kinase anchor protein 1, mitochondrial

2

3

High-throughput

0.584

High

245531

CLPB
Mitochondrial disaggregase

2

3

Small-scale

0.584

High

245539

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

245540

PLRKT
Plasminogen receptor

2

1

High-throughput

0.584

High

245460

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

0

Small-scale

0.569

High

245545

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

5

Small-scale

0.561

High

245521

YMEL1
ATP-dependent zinc metalloprotease YME1L1

2

0

High-throughput

0.559

High

179763

BET1
BET1 homolog

1

1

High-throughput

0.536

High

212623

DAPK3
Death-associated protein kinase 3

1

1

High-throughput

0.536

High

245405

S10A6
Protein S100-A6

1

2

High-throughput

0.536

High

245431

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

1

High-throughput

0.536

High

245438

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

245448

TPTE
Putative tyrosine-protein phosphatase TPTE

1

2

High-throughput

0.536

High

245458

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

1

High-throughput

0.536

High

245491

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

245523

CML1
Chemerin-like receptor 1

1

5

High-throughput

0.536

High

245563

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

166224

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

0

High-throughput

0.528

High

245456

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.515

High

245472

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.515

High

219888

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

245408

NEP
Neprilysin

1

0

Small-scale

0.513

High

245497

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.513

High

245406

NPM
Nucleophosmin

1

0

High-throughput

0.493

High

245424

PIT1
Pituitary-specific positive transcription factor 1

1

0

High-throughput

0.493

High

133221

P2Y10
Putative P2Y purinoceptor 10

1

4

High-throughput

0.489

High

245421

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.489

High

245426

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

245441

NPY2R
Neuropeptide Y receptor type 2

1

2

High-throughput

0.489

High

245462

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.489

High

245565

GPR45
Probable G-protein coupled receptor 45

1

6

High-throughput

0.489

High

245566

NPTN
Neuroplastin

1

3

High-throughput

0.489

High

104916

APRIO
Alternative prion protein

1

4

High-throughput

0.479

High

124162

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.479

High

163865

NDC80
Kinetochore protein NDC80 homolog

1

3

High-throughput

0.479

High

192146

YKT6
Synaptobrevin homolog YKT6

1

2

High-throughput

0.479

High

216581

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

245387

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

3

High-throughput

0.479

High

245390

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.479

High

245391

MTX2
Metaxin-2

1

2

High-throughput

0.479

High

245392

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

245395

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

245396

TOM70
Mitochondrial import receptor subunit TOM70

1

4

High-throughput

0.479

High

245397

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

245399

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.479

High

245400

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

245403

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

245407

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.479

High

245409

TPM1
Tropomyosin alpha-1 chain

1

4

High-throughput

0.479

High

245412

KCRU
Creatine kinase U-type, mitochondrial

1

4

High-throughput

0.479

High

245415

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

245416

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.479

High

245419

LMNB1
Lamin-B1

1

2

High-throughput

0.479

High

245422

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

245423

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

245428

PML
Protein PML

1

2

High-throughput

0.479

High

245430

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

245432

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

245433

MYH10
Myosin-10

1

2

High-throughput

0.479

High

245434

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

245437

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

6

High-throughput

0.479

High

245439

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

245440

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

245442

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

245443

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

245444

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

245449

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

245451

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

245452

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

245454

TPM4
Tropomyosin alpha-4 chain

1

4

High-throughput

0.479

High

245457

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

245459

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

245463

MTX1
Metaxin-1

1

2

High-throughput

0.479

High

245465

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.479

High

245466

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

6

High-throughput

0.479

High

245469

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

245470

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

245473

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

245474

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

245484

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

245486

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

245487

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

2

High-throughput

0.479

High

245492

LRC49
Leucine-rich repeat-containing protein 49

1

3

High-throughput

0.479

High

245494

MICU2
Calcium uptake protein 2, mitochondrial

1

1

High-throughput

0.479

High

245504

PHIP
PH-interacting protein

1

3

High-throughput

0.479

High

245506

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

245509

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

245512

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

Small-scale

0.479

High

245514

OPTN
Optineurin

1

4

High-throughput

0.479

High

245516

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.479

High

245517

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

245518

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

245519

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

245520

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

245522

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

245524

MIC25
MICOS complex subunit MIC25

1

2

High-throughput

0.479

High

245530

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

245532

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

245533

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.479

High

245535

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

245538

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

245546

DJC11
DnaJ homolog subfamily C member 11

1

4

High-throughput

0.479

High

245547

ATD3A
ATPase family AAA domain-containing protein 3A

1

12

High-throughput

0.479

High

245548

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

245550

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

245551

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

Small-scale

0.479

High

245552

MIC19
MICOS complex subunit MIC19

1

2

High-throughput

0.479

High

245554

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

245555

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

2

High-throughput

0.479

High

245556

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

245557

XPO7
Exportin-7

1

4

High-throughput

0.479

High

245558

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

245560

TDRKH
Tudor and KH domain-containing protein

1

2

High-throughput

0.479

High

245562

SAM50
Sorting and assembly machinery component 50 homolog

1

2

High-throughput

0.479

High

245564

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.479

High

126274

TLR4
Toll-like receptor 4

1

0

Small-scale

0.458

High

193913

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

245388

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.458

High

245389

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

245393

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

245414

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.458

High

245417

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

245418

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

245445

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

245446

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

245455

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

245461

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

245467

STAR3
StAR-related lipid transfer protein 3

1

0

High-throughput

0.458

High

245468

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

245488

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

245493

DRC7
Dynein regulatory complex subunit 7

1

0

High-throughput

0.458

High

245495

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

245496

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

245498

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

245499

MIGA1
Mitoguardin 1

1

0

High-throughput

0.458

High

245500

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

245501

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.458

High

245515

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

245526

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

245527

MTA3
Metastasis-associated protein MTA3

1

0

High-throughput

0.458

High

245528

DERL1
Derlin-1

1

0

High-throughput

0.458

High

245529

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

245534

TRABD
TraB domain-containing protein

1

0

High-throughput

0.458

High

245537

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.458

High

245541

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

245543

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

245553

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.458

High

245450

STXB1
Syntaxin-binding protein 1

1

1

High-throughput

0.457

High

245542

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

245410

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.445

High

245420

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.445

High

245425

GRN
Progranulin

1

1

High-throughput

0.445

High

245447

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

245471

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

High-throughput

0.445

High

245478

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

245481

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

2

High-throughput

0.445

High

245510

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.445

High

245567

MTCH2
Mitochondrial carrier homolog 2

1

6

High-throughput

0.445

High

245513

CHP3
Calcineurin B homologous protein 3

1

0

High-throughput

0.438

High

245427

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.437

High

245489

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

245505

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

245436

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.426

High

245536

HAUS4
HAUS augmin-like complex subunit 4

1

0

High-throughput

0.426

High

245559

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

245525

S39A3
Zinc transporter ZIP3

1

2

High-throughput

0.407

High

245544

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

245479

ZN776
Zinc finger protein 776

1

0

High-throughput

0.279

Low

245485

INSY2
Inhibitory synaptic factor 2A

1

0

High-throughput

0.279

Low

245511

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

245503

ENKUR
Enkurin

1

0

High-throughput

0.269

Low

245402

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.249

Low

245476

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

245480

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

245483

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

245508

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

0

High-throughput

0.249

Low

245561

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

245482

Q6NSK7
RIN3 protein

1

0

High-throughput

0.238

Low

245477

S35F1
Solute carrier family 35 member F1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025